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milrinone

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Origin: China

Cas No: 78415-72-2

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
78415-72-2
Other Names:
Milrinone
MF:
C18H15ClN2O2S, C18H15ClN2O2S
EINECS No.:
682-421-5
Place of Origin:
Shandong china, Shandong China
Type:
Antipyretic Analgesics and NSAIDs
Grade Standard:
Medicine Grade
Usage:
Animal Pharmaceuticals
Brand Name:
Fousi, Fousi
Model Number:
FS78415-72-2
Purity:
99%, 99%
Product name:
Milrinone
Form:
Powder
CAS:
78415-72-2
Appearance:
powder
EINECS:
278-903-6
Shelf life:
2 Years Proper Storage
Packaging&Delivery
Packaging Details
Bulk qty: 25kg/drum, inside two level plastic bags
Small qty: Aluminium bag, inside two level plastic bags
Others: can do your package or split small packages according to your request
Port
QINGDAO ,SHANGHAI
Lead Time:
Quantity(Grams) 1 - 1 >1
Est. Time(days) 7 To be negotiated

Property

CAS No.: 78415-72-2 Formula: C12H9N3O Molecular Weight: 211.21900

Description

Milrinone, commonly known and marketed under the brand name Primacor, is a medication used in patients who have heart failure. It is a phosphodiesterase 3 inhibitor that works to increase the heart's contractility and decrease pulmonary vascular resistance. Milrinone also works to vasodilate which helps alleviate increased pressures (afterload) on the heart, thus improving its pumping action. While it has been used in people with heart failure for many years, recent studies suggest that milrinone may exhibit some negative side effects that have caused some debate about its use clinically.
Overall, milrinone supports ventricular functioning of the heart by decreasing the degradation of cAMP and thus increasing phosphorylation levels of many components in the heart that contribute to contractility and heart rate. Milrinone use following cardiac surgery has been under some debate because of the potential increase risk of postoperative atrial arrhythmias. However, in the short term milrinone has been deemed beneficial to those experiencing heart failure and an effective therapy to maintain heart function following cardiac surgeries. There is no evidence of any long term beneficial effects on survival.

Basic Info

Chemical Name	milrinone
Synonyms	Milrinonum; 1,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile; Primacor; Corotrop; Milrila; Milrinone; 6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile; Corotrope; Milrinona; 2-methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile;
CAS No.	78415-72-2
Molecular Formula	C12H9N3O
Molecular Weight	211.21900
PSA	69.54000
LogP	1.61698

Properties

Appearance & Physical State	Off-white solid
Density	1.28 g/cm3
Boiling Point	448.7ºC at 760 mmHg
Melting Point	>300ºC
Flash Point	225.2ºC
Stability	Stable. Incompatible with strong oxidizing agents.
Storage Condition	2-8ºC

Safety Info

RTECS	DW1762000
Hazard Class	6.1(b)
Safety Statements	S36/37/39-S45
HS Code	2933399090
WGK Germany	3
Packing Group	III
RIDADR	UN 2811
Risk Statements	R23/24/25
Hazard Codes	T

Synthesis Route

carbon atom+4-(Dimethylamino)-3-(4-pyridyl)-3-buten-2-one→milrinone
4-Pyridyl acetone+Ethoxymethylenemalononitrile→milrinone
4-(Dimethylamino)-3-(4-pyridyl)-3-buten-2-one+2-Cyanoacetamide→milrinone

Precursor

2-Cyanoacetamide
4-(Dimethylamino)-3-(4-pyridyl)-3-buten-2-one
Ethoxymethylenemalononitrile
4-Pyridyl acetone

Downstream Product

2-chloro-6-methyl-5-pyridin-4-ylpyridine-3-carbonitrile
6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carboxamide

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