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Lubiprostone

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Origin: China

Cas No: 136790-76-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
136790-76-6
Place of Origin:
Hubei, China
Type:
Pharmaceutical Intermediates
Purity:
99
Appearance:
white powder
purity:
99
Shelf life:
2 years
Assay:
99
Packing:
drum
Package:
as customer's request
Form:
powder
Color:
white
Storage:
Cool
Test:
HPLC
cas:
136790-76-6
Packaging&Delivery
Selling Units:
Single item
Single package size:
35X34X40 cm
Single gross weight:
0.500 kg
Package Type:
```
bag/drum
```
Lead Time:
Quantity(Grams) 1 - 100 >100
Est. Time(days) 10 To be negotiated

Property

CAS No.: 136790-76-6 Formula: C20H32F2O5 Molecular Weight: 390.46200

Description

Lubiprostone (rINN, marketed under the trade name Amitiza among others) is a medication used in the management of chronic idiopathic constipation, predominantly irritable bowel syndrome-associated constipation in women and opioid-induced constipation.
It was initially approved by the U.S. Food and Drug Administration (FDA) in 2006. It is very expensive as of 2012.

Basic Info

Chemical Name	Lubiprostone
Synonyms	13,14-Dihydro-15-keto-PGD2; 13,14-Dihydro-15-ketoprostadlandin D2; 13,14-dihydro-15-keto-16,16-difluoro-Prostaglandin E1; 9ALPHA-HYDROXY-11,15-DIOXO-PROST-5Z-EN-1-OIC ACID; 13,14-dihydro-15-keto Prostaglandin D2 Lipid Maps MS Standard; DK-PGD2; 13,14-dihydro-15-keto PD2; 13,14-dihydro-15-keto-prostaglandin D2; 13,14-dihydro-15-keto-16,16-difluoro-PGE1;
CAS No.	136790-76-6
Molecular Formula	C20H32F2O5
Molecular Weight	390.46200
PSA	83.83000
LogP	4.30990

Properties

Appearance & Physical State	white, odorless crystals or crystalline powder
Density	1.175 g/cm3
Boiling Point	532.3ºC at 760 mmHg
Melting Point	56-59ºC
Flash Point	275.7ºC
Refractive Index	1.486
Vapor Pressure	1.49E-13mmHg at 25°C

Safety Info

HS Code	2918990090
Hazard Declaration	H315; H319; H335
Caution Statement	P261; P305 + P351 + P338
Symbol	GHS07
Signal Word	Warning

Synthesis Route

benzyl (Z)-7-[(1R,2R,3R)-2-((E)-4,4-difluoro-3-oxo-1-octenyl)-3-(phenylmethoxy)-5-oxocyclopentyl]-5-heptenoate→Lubiprostone
(Z)-7-[(1R,2R,3R)-2-((E)-4,4-difluoro-3-oxo-1-octenyl)-3-(phenylmethoxy)-5-oxocyclopentyl]-5-heptenoic acid→Lubiprostone
[(3aR,4R,5R,6aS)-hexahydro-2-oxo-5-(phenylmethoxy)-2H-cyclopenta[b]furan-4-carboxaldehyde]→Lubiprostone

Precursor

[(3aR,4R,5R,6aS)-hexahydro-2-oxo-5-(phenylmethoxy)-2H-cyclopenta[b]furan-4-carboxaldehyde]
[(3aR,4S,5R,6aS)-hexahydro-5-hydroxy-4(triisopropylsilyloxymethyl)-2H-cyclopenta[b]furan-2-one]
(3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-one
benzyl (Z)-7-[(1R,2R,3R)-2-((E)-4,4-difluoro-3-oxo-1-octenyl)-3-(phenylmethoxy)-5-oxocyclopentyl]-5-heptenoate

Downstream Product

(2R,4aR,5R,7aR)-2-(1,1-Difluoropentyl)-2-hydroxy-6-oxo-3,4,4a,5,7,7a-hexahydrocyclopenta[b]pyran-5-heptanoic acid

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