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Lubiprostone

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Origin: China

Cas No: 136790-76-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description
  • Quick Details

    CAS No.:
    136790-76-6
    Place of Origin:
    Hubei, China
    Type:
    Pharmaceutical Intermediates
    Purity:
    99
    Appearance:
    white powder
    purity:
    99
    Shelf life:
    2 years
    Assay:
    99
    Packing:
    drum
    Package:
    as customer's request
    Form:
    powder
    Color:
    white
    Storage:
    Cool
    Test:
    HPLC
    cas:
    136790-76-6

    Packaging&Delivery

    Selling Units:
    Single item
    Single package size: 
    35X34X40 cm
    Single gross weight:
    0.500 kg
    Package Type:
    bag/drum
    Lead Time:
    Quantity(Grams)1 - 100>100
    Est. Time(days)10To be negotiated
  • Property

    CAS No.: 136790-76-6 Formula: C20H32F2O5 Molecular Weight: 390.46200

    Description

    Lubiprostone (rINN, marketed under the trade name Amitiza among others) is a medication used in the management of chronic idiopathic constipation, predominantly irritable bowel syndrome-associated constipation in women and opioid-induced constipation.
    It was initially approved by the U.S. Food and Drug Administration (FDA) in 2006. It is very expensive as of 2012.

    Basic Info

    Chemical Name Lubiprostone
    Synonyms

    13,14-Dihydro-15-keto-PGD2;
    13,14-Dihydro-15-ketoprostadlandin D2;
    13,14-dihydro-15-keto-16,16-difluoro-Prostaglandin E1;
    9ALPHA-HYDROXY-11,15-DIOXO-PROST-5Z-EN-1-OIC ACID;
    13,14-dihydro-15-keto Prostaglandin D2 Lipid Maps MS Standard;
    DK-PGD2;
    13,14-dihydro-15-keto PD2;
    13,14-dihydro-15-keto-prostaglandin D2;
    13,14-dihydro-15-keto-16,16-difluoro-PGE1;

    CAS No. 136790-76-6
    Molecular Formula C20H32F2O5
    Molecular Weight 390.46200
    PSA 83.83000
    LogP 4.30990

    Properties

    Appearance & Physical State white, odorless crystals or crystalline powder
    Density 1.175 g/cm3
    Boiling Point 532.3ºC at 760 mmHg
    Melting Point 56-59ºC
    Flash Point 275.7ºC
    Refractive Index 1.486
    Vapor Pressure 1.49E-13mmHg at 25°C

    Safety Info

    HS Code 2918990090
    Hazard Declaration H315; H319; H335
    Caution Statement P261; P305 + P351 + P338
    Symbol GHS07
    Signal Word Warning

    Synthesis Route

    benzyl (Z)-7-[(1R,2R,3R)-2-((E)-4,4-difluoro-3-oxo-1-octenyl)-3-(phenylmethoxy)-5-oxocyclopentyl]-5-heptenoateLubiprostone
    (Z)-7-[(1R,2R,3R)-2-((E)-4,4-difluoro-3-oxo-1-octenyl)-3-(phenylmethoxy)-5-oxocyclopentyl]-5-heptenoic acidLubiprostone
    [(3aR,4R,5R,6aS)-hexahydro-2-oxo-5-(phenylmethoxy)-2H-cyclopenta[b]furan-4-carboxaldehyde]Lubiprostone

    Precursor

    [(3aR,4R,5R,6aS)-hexahydro-2-oxo-5-(phenylmethoxy)-2H-cyclopenta[b]furan-4-carboxaldehyde]
    [(3aR,4S,5R,6aS)-hexahydro-5-hydroxy-4(triisopropylsilyloxymethyl)-2H-cyclopenta[b]furan-2-one]
    (3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-one
    benzyl (Z)-7-[(1R,2R,3R)-2-((E)-4,4-difluoro-3-oxo-1-octenyl)-3-(phenylmethoxy)-5-oxocyclopentyl]-5-heptenoate

    Downstream Product

    (2R,4aR,5R,7aR)-2-(1,1-Difluoropentyl)-2-hydroxy-6-oxo-3,4,4a,5,7,7a-hexahydrocyclopenta[b]pyran-5-heptanoic acid

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