Home > Chiral Compounds> Levcromakalim,(3S,4R)-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile

Levcromakalim,(3S,4R)-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile

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Origin: China

Cas No: 94535-50-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 94535-50-9 Formula: C16H18N2O3 Molecular Weight: 286.32600

Description

Levcromakalim is a potassium channel activator and vasorelaxant used in the management of hypertension in diabetes mellitus.

Basic Info

Chemical Name	Levcromakalim,(3S,4R)-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile
Synonyms	levcromakelim; lemakalim; levcromakalim;
CAS No.	94535-50-9
Molecular Formula	C16H18N2O3
Molecular Weight	286.32600
PSA	73.56000
LogP	1.69158

Properties

Density	1.31g/cm3
Boiling Point	482.3ºC at 760mmHg
Flash Point	245.5ºC

Safety Info

HS Code	2934999090

Synthesis Route

pyrrolidin-2-one+2H-Oxireno[c][1]benzopyran-6-carbonitrile, 1a,7b-dihydro-2,2-dimethyl-→Levcromakalim,(3S,4R)-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile
2,2-dimethylchromene-6-carbonitrile→Levcromakalim,(3S,4R)-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile
(±)-Cromakalim→Levcromakalim,(3S,4R)-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile+3-Hydroxy-2,2-dimethyl-4-(2-oxo-pyrrolidin-1-yl)-chroman-6-carbonitrile

Precursor

2H-Oxireno[c][1]benzopyran-6-carbonitrile, 1a,7b-dihydro-2,2-dimethyl-
pyrrolidin-2-one
2,2-dimethylchromene-6-carbonitrile
(±)-Cromakalim

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