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1-Acetyl-5-(2-aminopropyl)indoline-7-carbonitrile

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Origin: China

Cas No: 175837-01-1

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

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CAS No.: 175837-01-1 Formula: C14H17N3O Molecular Weight: 243.30400

Description

1-Acetyl-5-(2-aminopropyl)indoline-7-carbonitrile is an intermediate in the synthesis of Silodosin, an α1a-adrenoceptor antagonist. It is used in treatment of benign prostatic hypertophy.

Basic Info

Chemical Name	1-Acetyl-5-(2-aminopropyl)indoline-7-carbonitrile
Synonyms	1-acetyl-5-(2-aminopropyl)-2,3-dihydroindole-7-carbonitrile;
CAS No.	175837-01-1
Molecular Formula	C14H17N3O
Molecular Weight	243.30400
PSA	70.12000
LogP	2.12228

Properties

Density	1.19
Boiling Point	498.585ºC at 760 mmHg
Flash Point	255.335ºC

Safety Info

HS Code	2933990090

Synthesis Route

1-acetyl-5-(2-azidopropyl)indoline-7-carbonitrile→1-Acetyl-5-(2-aminopropyl)indoline-7-carbonitrile
→1-Acetyl-5-(2-aminopropyl)indoline-7-carbonitrile+1-acetyl-5-(2-azidopropyl)indoline-7-carbonitrile

Precursor

1-acetyl-5-(2-azidopropyl)indoline-7-carbonitrile

Downstream Product

Silodosin
(R)-1-(3-Hydroxypropyl)-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carbonitrile
(R)-tert-butyl(1-(1-allyl-7-cyanoindolin-5-yl)propan-2-yl)(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)carbamate
(R)-tert-butyl(1-(7-cyano-1-(3-hydroxypropyl)indolin-5-yl)propan-2-yl)(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)carbamate

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