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leukotriene B4

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Origin: China

Cas No: 71160-24-2

Specification: 99%min

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 71160-24-2 Formula: C20H32O4 Molecular Weight: 336.46600

    Description

    Leukotriene B4 is a leukotriene involved in inflammation. It is produced from leukocytes in response to inflammatory mediators and is able to induce the adhesion and activation of leukocytes on the endothelium, allowing them to bind to and cross it into the tissue. In neutrophils, it is also a potent chemoattractant, and is able to induce the formation of reactive oxygen species and the release of lysosomal enzymes by these cells. It is synthesized by leukotriene-A4 hydrolase from leukotriene A4.
    Eicosanoid synthesis. (Leukotrienes at right.)

    Basic Info

    Chemical Name leukotriene B4
    Synonyms

    6Z,8E,10E,14Z,5S,12R-diHETE;
    Leukotriene B4,(5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxy-6,8,10,14-eicosatetraenoicacid;
    LTB4;
    Leukotriene B4 Lipid Maps MS Standard;
    LEUKOTRIENE B4;

    CAS No. 71160-24-2
    Molecular Formula C20H32O4
    Molecular Weight 336.46600
    PSA 77.76000
    LogP 4.15830

    Properties

    Density 1.04g/cm3
    Boiling Point 536.37ºC at 760 mmHg
    Flash Point 14ºC
    Refractive Index 1.527
    Storage Condition -20ºC

    Safety Info

    Safety Statements S; S7; S16
    WGK Germany 1
    RIDADR UN 1170 3/PG 2
    Risk Statements R11
    Hazard Codes F
    Signal Word Danger
    Hazard Declaration H225; H319
    Caution Statement P210; P280; P305 + P351 + P338; P337 + P313; P403 + P235
    Symbol GHS02, GHS07

    Synthesis Route

    Methyl (5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxyeicosa-6,8,10,14-tetraenoate→leukotriene B4
    (5S,6Z,8E,10E,12R,14Z)-methyl 5,12-bis((tert-butyldiphenylsilyl)oxy)-6,8,10,14-eicosatetraenoate→leukotriene B4
    Methyl 4-(chloroformyl)butyrate→leukotriene B4

    Precursor

    (5S,6Z,8E,10E,12R,14Z)-methyl 5,12-bis((tert-butyldiphenylsilyl)oxy)-6,8,10,14-eicosatetraenoate
    Methyl 4-(chloroformyl)butyrate
    5(S),12(R)-bis[(tert-butyldimethylsilyl)oxy]-6(7),8(E),10(E),14(Z)-eicosatetraenoic acid
    Methyl (5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxyeicosa-6,8,10,14-tetraenoate

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