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L-thyroxine

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Origin: China

Cas No: 51-48-9

Specification: 99%min

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Supply Ability: 100 mt/month

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 51-48-9 Formula: C15H11I4NO4 Molecular Weight: 776.87000

    Description

    Levothyroxine, also known as L-thyroxine, is a synthetic thyroid hormone that is chemically identical to thyroxine (T4), which is naturally secreted by the follicular cells of the thyroid gland. It is used to treat thyroid hormone deficiency, and occasionally to prevent the recurrence of thyroid cancer. Like its naturally secreted counterpart, levothyroxine is a chiral compound in the L-form. The related drug dextrothyroxine (D-thyroxine) was used in the past as a treatment for hypercholesterolemia (elevated cholesterol levels) but was withdrawn due to cardiac side effects.
    It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.

    Basic Info

    Chemical Name L-thyroxine
    Synonyms

    3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine;
    L-Thyroxine;
    Henning;
    thyroxin;
    L-THYROXIN;
    tetraiodothyronine;
    3,5,3',5'-tetraiodothyronine;
    L-3,5,3',5'-tetraiodothyronine;
    thyroxinal;
    thx;
    Thyrax;
    l-t4;
    3,3’,5,5‘’-Tetraiodo-L-thyronine;
    L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-;
    thyroxine-binding globulin;
    THYROXINE;
    Levothyroxine;

    CAS No. 51-48-9
    Molecular Formula C15H11I4NO4
    Molecular Weight 776.87000
    PSA 92.78000
    LogP 5.25760

    Properties

    Appearance & Physical State Beige powder.
    Density 2.635g/cm3
    Boiling Point 576.3ºC at 760mmHg
    Melting Point 223ºC (dec.)
    Flash Point 302.3ºC
    Refractive Index 1.795
    Water Solubility insoluble
    Stability Stable under normal temperatures and pressures.
    Storage Condition 2-8ºC

    Safety Info

    RTECS YP2833500
    Safety Statements S24/25
    HS Code 2942000000
    WGK Germany 3
    Risk Statements R20/21/22
    Hazard Codes Xn

    Synthesis Route

    3,5-Diiodo-L-thyronine→L-thyroxine
    thyroxine→L-thyroxine+D-thyroxine
    N-Acetyl-3,5-diiodo-L-tyrosine→L-thyroxine

    Precursor

    methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoate
    3,5-Diiodo-L-thyronine
    thyroxine
    L-Tyrosine

    Downstream Product

    Naphtho[1,8-cd]-1,2-thiaselenole
    1,2-Dithiaacenaphthene
    N-Acetyl L-Thyroxine
    3,3',5'-triiodothyronine

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