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L-kynurenine

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Origin: China

Cas No: 2922-83-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 2922-83-0 Formula: C10H12N2O3 Molecular Weight: 208.21400

Description

L-Kynurenine is a metabolite of the amino acid L-tryptophan used in the production of niacin.
Kynurenine is synthesized by the enzyme tryptophan dioxygenase, which is made primarily but not exclusively in the liver, and indoleamine 2,3-dioxygenase, which is made in many tissues in response to immune activation. Kynurenine and its further breakdown products carry out diverse biological functions, including dilating blood vessels during inflammation and regulating the immune response. Some cancers increase kynurenine production, which increases tumor growth.
Evidence suggests that increased kynurenine production may precipitate depressive symptoms associated with interferon treatment for hepatitis C. Cognitive deficits in schizophrenia are associated with imbalances in the enzymes that break down kynurenine. Kynurenine production is increased in Alzheimer's disease and cardiovascular disease where its metabolites are associated with cognitive deficits and depressive symptoms. Kynurenine is also associated with tics.
Kynureninase catabolizes the conversion of kynurenine into anthranilic acid while kynurenine-oxoglutarate transaminase catabolizes its conversion into kynurenic acid. Kynurenine 3-hydroxylase converts kynurenine to 3-hydroxykynurenine.

Basic Info

Chemical Name	L-kynurenine
Synonyms	L-KYNURENINE; Kynurenine; L-Kynurenin; (S)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid;
CAS No.	2922-83-0
Molecular Formula	C10H12N2O3
Molecular Weight	208.21400
PSA	106.41000
LogP	1.53500

Properties

Appearance & Physical State	light yellow crystalline
Density	1.343 g/cm3
Boiling Point	466.6ºC at 760 mmHg
Flash Point	236ºC

Safety Info

HS Code	2922509090

Synthesis Route

kynurenine→L-kynurenine+D-kynurenine
(2S)-Methyl 2-(N-tert-butoxycarbonylamino)-4-oxo-4-(2'-aminophenyl)butanoate→L-kynurenine
L-tryptophan→L-kynurenine

Precursor

2-Iodoaniline
L-tryptophan
(2S)-Methyl 2-(N-tert-butoxycarbonylamino)-4-oxo-4-(2'-aminophenyl)butanoate
L-Kynurenine dihydrobromide

Downstream Product

L-alanine
2-Amino-3,5-dibromobenzoic acid
3-amino-1-(2-aminophenyl)propan-1-one
anthranilic acid

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