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indometacin

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Origin: China

Cas No: 53-86-1

Specification: 99%min

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 53-86-1 Formula: C19H16ClNO4 Molecular Weight: 357.78800

    Description

    Indometacin (INN and BAN) or indomethacin (AAN, USAN and former BAN) is a nonsteroidal anti-inflammatory drug (NSAID) commonly used as a prescription medication to reduce fever, pain, stiffness, and swelling from inflammation. It works by inhibiting the production of prostaglandins, molecules known to cause these symptoms.
    It is marketed under more than twelve different trade names. As of 2015 the cost for a typical month of medication in the United States is less than 25 USD.

    Basic Info

    Chemical Name indometacin
    Synonyms

    Lausit;
    Vonum;
    Catlep;
    Amuno;
    Tannex;
    Bonidin;
    Dolovin;
    INDOCIN;
    Indacin;
    Inacid;
    Indometacin;
    Indomethacin;
    1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic Acid;
    2-(1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid;

    CAS No. 53-86-1
    Molecular Formula C19H16ClNO4
    Molecular Weight 357.78800
    PSA 68.53000
    LogP 3.92730

    Properties

    Appearance & Physical State White crystalline powder
    Density 1.32g/cm3
    Boiling Point 499.4ºC at 760 mmHg
    Melting Point 155-162ºC
    Flash Point 255.8ºC
    Stability Stable. Incompatible with strong oxidizing agents.
    Storage Condition Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

    Safety Info

    RTECS NL3500000
    Hazard Class 6.1
    Safety Statements S28-S36/37-S45
    HS Code 2933290090
    WGK Germany 3
    Packing Group I
    RIDADR UN 2811
    Risk Statements R28
    Hazard Codes T+
    Signal Word Danger
    Caution Statement P264; P301 + P310
    Symbol GHS06
    Hazard Declaration H300

    Synthesis Route

    (4-methoxyphenyl)hydrazine,hydrochloride+4-chlorobenzoyl chloride→indometacin
    2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetaldehyde→indometacin
    indomethacin benzyl ester→indometacin

    GC Analysis

    Column type Active phase Temperature (°C) Retention Index (I) Temperature Control Method
    Packed OV-101 - 2680. custom temperature program
    Other Methyl Silicone - 2685. custom temperature program

    Precursor

    4-oxopentanoic acid
    4-chlorobenzoyl chloride
    2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetaldehyde
    indomethacin benzyl ester

    Downstream Product

    N-(2-Phenylethyl)indomethacin Amide
    1-(4-chlorobenzoyl)-5-methoxy-2-methylindole-3-carbaldehyde
    O-Desmethyl Indomethacin
    2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-1-morpholin-4-ylethanone

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