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ICI-118,551

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Origin: China

Cas No: 72795-19-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 72795-19-8 Formula: C17H28ClNO2 Molecular Weight: 313.86300

Description

ICI-118,551 is a selective β2 adrenergic receptor (adrenoreceptor) antagonist. ICI binds to the β2 subtype with at least 100 times greater affinity than β1 or β3, the two other known subtypes of the beta adrenoceptor. The compound was developed by Imperial Chemical Industries, which was acquired by AkzoNobel in 2008.
ICI-118,551 has no known therapeutic use in humans although it has been used widely in research to understand the action of the β2 adrenergic receptor, as few other specific antagonists for this receptor are known. When dissolved in saline, the compound crosses the blood–brain barrier. Common systemic doses used in rodent research are 0.5 or 1mg/kg although efficacy has been demonstrated at doses as low as 0.0001mg/kg in rhesus monkeys. Doses up to 20mg/kg have been used without toxicity. At room temperature in saline, the ICI 118,551 hydrochloride is soluble to at least 2.5mg/mL.

Basic Info

Chemical Name	ICI-118,551
Synonyms	ICI 118,551 HYDROCHLORIDE; Ici 111,581; ICI-118-551 HYDROCHLORIDE HIGHLY SELECTI VE B2 A;
CAS No.	72795-19-8
Molecular Formula	C17H28ClNO2
Molecular Weight	313.86300
PSA	41.49000
LogP	3.80280