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Fumaric Acid Monomethyl Ester

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Origin: China

Cas No: 2756-87-8

Specification: 99%min

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Supply Ability: 50 mt/month

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 2756-87-8 Formula: C5H6O4 Molecular Weight: 130.09900

    Description

    Fumaric acid monomethyl ester is one of the most bioactive anti-psoriatic fumaric acid ester metabolite. Fumaric acid monomethyl ester is potent nicotinic acid receptor agonist. Fumaric acid monomethyl ester has also been shown to selectively stimulate of T helper 2 cytokine response. It is also the active metabolite of Dimethyl Fumarate, a compound that is used as a treatment for the relapsing forms of multiple sclerosis and psoriasis.

    Basic Info

    Chemical Name Fumaric Acid Monomethyl Ester
    Synonyms

    Monomethyl fumarate;
    Methyl Hydrogen Fumarate;
    4-Methoxy-4-oxobut-2-enoic acid;

    CAS No. 2756-87-8
    Molecular Formula C5H6O4
    Molecular Weight 130.09900
    PSA 63.60000
    LogP -0.19980

    Properties

    Density 1.265 g/cm3
    Boiling Point 250ºC at 760mmHg
    Melting Point 144-145ºC
    Flash Point 108.9ºC
    Refractive Index 1.468
    Vapor Pressure 0.00706mmHg at 25°C

    Safety Info

    Safety Statements S26-S39
    HS Code 2918990090
    WGK Germany 3
    Risk Statements R41
    Hazard Codes Xi

    Synthesis Route

    Methanol+fumaric acid→Fumaric Acid Monomethyl Ester+dimethyl fumarate
    2-Butenedioic acid, monomethyl ester→Fumaric Acid Monomethyl Ester
    dimethyl fumarate→Fumaric Acid Monomethyl Ester

    Precursor

    trans-Methyl crotonate
    dimethyl fumarate
    maleic anhydride
    2-Butenedioic acid, monomethyl ester

    Downstream Product

    Fumaric acid monoamide
    2-(3-oxo-4H-1,4-benzothiazin-2-yl)acetic acid
    2-(2-amino-4-oxo-1,3-thiazol-5-yl)acetic acid
    methyl 2-(3-oxo-4H-1,4-benzothiazin-2-yl)acetate

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