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finasteride

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Origin: China

Cas No: 98319-26-7

Specification: 99%min

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 98319-26-7 Formula: C23H36N2O2 Molecular Weight: 372.54400

    Description

    Finasteride, sold under the brand names Proscar and Propecia among others, is a medication used for the treatment of benign prostatic hyperplasia (BPH) and male pattern baldness (MPB). It is a type II and type III 5α-reductase inhibitor; 5α-reductase, an enzyme, converts testosterone to dihydrotestosterone (DHT).

    Basic Info

    Chemical Name finasteride
    Synonyms

    Finastid;
    MK-906;
    Chibro-Proscar;
    (1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-tert-butyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide;
    Finpecia;
    Finasterida;
    Prostide;
    Propecia;
    Proscar;
    Finasteride;
    Finasteridum;

    CAS No. 98319-26-7
    Molecular Formula C23H36N2O2
    Molecular Weight 372.54400
    PSA 58.20000
    LogP 4.53420

    Properties

    Appearance & Physical State white to off-white crystalline powder
    Density 1.065 g/cm3
    Boiling Point 576.6ºC at 760 mmHg
    Melting Point 253ºC
    Flash Point 177.4ºC
    Refractive Index 1.524
    Water Solubility insoluble

    Safety Info

    RTECS CL5245000
    Safety Statements S36/37/39-S45-S53
    HS Code 2937290090
    WGK Germany 3
    Risk Statements R22; R60; R61
    Hazard Codes T

    Synthesis Route

    Dihydro Finasteride→finasteride
    N-tert-butyl-2-phenylsulfenyl-3-oxo-4-aza-5α-androstane-17β-carboxamide→finasteride
    methyl (1S,3aS,3bS,5aR,9aR,9bS,11aS)-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxylate→finasteride

    Precursor

    N-tert-butyl-2-phenylsulfenyl-3-oxo-4-aza-5α-androstane-17β-carboxamide
    methyl (1S,3aS,3bS,5aR,9aR,9bS,11aS)-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxylate
    Methylparaben
    propylparaben

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