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etretinate

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Origin: China

Cas No: 54350-48-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 54350-48-0 Formula: C23H30O3 Molecular Weight: 354.48300

Description

Etretinate (trade name Tegison) is a medication developed by Hoffmann–La Roche that was approved by the FDA in 1986 to treat severe psoriasis. It is a second-generation retinoid. It was subsequently removed from the Canadian market in 1996 and the United States market in 1998 due to the high risk of birth defects. It remains on the market in Japan as Tigason.

Basic Info

Chemical Name	etretinate
Synonyms	ethyl (all-E)-9-(4-methyoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoate; Retinoid; 9-(4-methoxy-2,3,6-trimethyl-phenyl)-3,7-dimethyl-nona-2,4,6,8-tetraen-1-oic acid ethyl ester; Ethyl etrinoate; Ro 10-9359; Etretinatum [INN-Latin]; Etretinato; ethyl (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoate; Etretinatum; ethyl all-trans-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoate; Etretinato [INN-Spanish]; Tegison;
CAS No.	54350-48-0
Molecular Formula	C23H30O3
Molecular Weight	354.48300
PSA	35.53000
LogP	5.64550

Properties

Appearance & Physical State	Crystalline solid
Density	1.006g/cm3
Boiling Point	506.4ºC at 760 mmHg
Melting Point	104-105ºC
Flash Point	219.4ºC
Refractive Index	1.544
Storage Condition	Amber Vial, -20ºC Freezer

Synthesis Route

Ethyl-4-hydroxy-9-(4-methyoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,5,7-trienoat→etretinate+ethyl (2E,4E,6Z,8E)-9-(4-methyoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoate
Ethyl 3-methyl-4-oxocrotonate→etretinate
3-methylpent-1-en-4-yn-3-ol→etretinate

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	TDLo - Lowest published toxic dose	Human	78 mg/kg/26W-I	1.Skin and Appendages-dermatitis, other (after systemic exposure) 2.Skin and Appendages-hair 3.Skin and Appendages-nails
Oral	TDLo - Lowest published toxic dose	Human - woman	60 mg/kg/17W-I	1.Skin and Appendages-hair
Oral	TDLo - Lowest published toxic dose	Human - woman	80 ug/kg/8D-I	1.Liver-other changes 2.Skin and Appendages-dermatitis, other (after systemic exposure) 3.Nutritional and Gross Metabolic-body temperature increase