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Изображение etretinate

etretinate

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начало: Китай

Кас Но: 54350-48-0

Спецификация: 99%наименьший

минимальный объем заказа: 1 /kg

снабженческая способность: 100 mt/month

опережающий период: OEM 7 дней, пятно 3 дня

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  • Характеристики продукции
  • Описание продукта

  • Property

    CAS No.: 54350-48-0 Formula: C23H30O3 Molecular Weight: 354.48300

    Description

    Etretinate (trade name Tegison) is a medication developed by Hoffmann–La Roche that was approved by the FDA in 1986 to treat severe psoriasis. It is a second-generation retinoid. It was subsequently removed from the Canadian market in 1996 and the United States market in 1998 due to the high risk of birth defects. It remains on the market in Japan as Tigason.

    Basic Info

    Chemical Name etretinate
    Synonyms

    ethyl (all-E)-9-(4-methyoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoate;
    Retinoid;
    9-(4-methoxy-2,3,6-trimethyl-phenyl)-3,7-dimethyl-nona-2,4,6,8-tetraen-1-oic acid ethyl ester;
    Ethyl etrinoate;
    Ro 10-9359;
    Etretinatum [INN-Latin];
    Etretinato;
    ethyl (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoate;
    Etretinatum;
    ethyl all-trans-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoate;
    Etretinato [INN-Spanish];
    Tegison;

    CAS No. 54350-48-0
    Molecular Formula C23H30O3
    Molecular Weight 354.48300
    PSA 35.53000
    LogP 5.64550

    Properties

    Appearance & Physical State Crystalline solid
    Density 1.006g/cm3
    Boiling Point 506.4ºC at 760 mmHg
    Melting Point 104-105ºC
    Flash Point 219.4ºC
    Refractive Index 1.544
    Storage Condition Amber Vial, -20ºC Freezer

    Synthesis Route

    Ethyl-4-hydroxy-9-(4-methyoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,5,7-trienoat→etretinate+ethyl (2E,4E,6Z,8E)-9-(4-methyoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoate
    Ethyl 3-methyl-4-oxocrotonate→etretinate
    3-methylpent-1-en-4-yn-3-ol→etretinate

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Oral TDLo - Lowest published toxic dose Human 78 mg/kg/26W-I 1.Skin and Appendages-dermatitis, other (after systemic exposure)
    2.Skin and Appendages-hair
    3.Skin and Appendages-nails
    Oral TDLo - Lowest published toxic dose Human - woman 60 mg/kg/17W-I 1.Skin and Appendages-hair
    Oral TDLo - Lowest published toxic dose Human - woman 80 ug/kg/8D-I 1.Liver-other changes
    2.Skin and Appendages-dermatitis, other (after systemic exposure)
    3.Nutritional and Gross Metabolic-body temperature increase

    Precursor

    2,3,5-Trimethyl-4-(3-methylpent-2-en-4-inyl)anisol
    2,3,5-TRIMETHYLANISOLE
    Ethyl 3-methyl-4-oxocrotonate
    3-methylpent-1-en-4-yn-3-ol

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