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etonogestrel

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Origin: China

Cas No: 54048-10-1

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
54048-10-1
Other Names:
Etonogestrel
MF:
C22H28O2
EINECS No.:
258-936-2
Place of Origin:
Hubei, China
Type:
Auxiliaries and Other Medicinal Chemicals
Grade Standard:
Medicine Grade
Brand Name:
Jayusion
Model Number:
Ja
Purity:
99%
Appearance:
White Powder
Melting point:
182-184°C
Packaging&Delivery
Packaging Details
500g/1kg/bag with foil bag
Port
Wuhan;Shanghai
Lead Time:
Quantity(Grams) 1 - 100 >100
Est. Time(days) 7 To be negotiated

Property

CAS No.: 54048-10-1 Formula: C22H28O2 Molecular Weight: 324.45700

Description

Ethinyl estradiol, also sometimes written as 17α-ethinyl estradiol, ethinylestradiol, ethynyl estradiol, or ethinyl œstradiol, is a derivative of 17β-estradiol (E2), the major endogenous estrogen in humans. EE2 is an orally bioactive estrogen used in many formulations of combined oral contraceptive pills and is one of the most commonly used medications for this purpose.
Transdermal ethinyl estradiol carries a greater risk of clot formation and venous thromboembolism than naturally occurring 17β-estradiol, which some have theorized to be related to different amounts of hepatic metabolism after absorption. The same contraindications and precautions apply for EE2 as with other estrogen medications.
Estinyl was a preparation of EE2 alone that was used for the management of menopausal symptoms and female hypogonadism.
EE2 is released into the environment as a xenoestrogen from the urine and feces of people who take it as a medication.
The major concern with unopposed estrogen (without progestogen) is of endometrial cancer. As such, the medication is generally prescribed with progesterone in the setting of birth control.

Basic Info

Chemical Name	etonogestrel
Synonyms	Etonogestrel; 3-oxodesogestrel; 3-keto-Desogestrel; Desogestrel Related Compound C (25 mg) (3-Keto-desogestrel); 3-Ketodesogestrel,3-Oxodesogestrel,Org-3236,Implanon; Etonoestrel; 3-Keto-desogestrel 3-Oxo-desogestrel; Implanon; [3H]-3-keto-Desogestrel; org3236;
CAS No.	54048-10-1
Molecular Formula	C22H28O2
Molecular Weight	324.45700
PSA	37.30000
LogP	4.04870

Properties

Appearance & Physical State	White or almost white crystalline powder
Density	1.13 g/cm3
Boiling Point	473.1ºC at 760 mmHg
Melting Point	182-184ºC
Flash Point	201.1ºC
Refractive Index	1.574
Storage Condition	-20ºC

Safety Info

Symbol	GHS08
Hazard Declaration	H351; H360
Caution Statement	P201; P281; P308 + P313
Signal Word	Danger

Synthesis Route

(8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-11-methylene-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate→etonogestrel
desogestrel→etonogestrel
13-ethyl-gona-4-ene-11α,17β-diol→etonogestrel

Precursor

13-ethyl-gona-4-ene-11α,17β-diol
18a-homo-estr-4-ene-11,17-dione
(8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-11-methylene-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate
(8S,9S,10R,14S)-13-Ethyl-11-methylene-2,3,7,8,9,10,11,12,13, 14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17(6H)-one

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