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Ethyl (3R,S)-2,2-difluoro-3-hydroxy-3-(2,2-dimethyldioxolan-4-yl)propionate

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Origin: China

Cas No: 95058-92-7

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
95058-92-7
Other Names:
propionate (T3), propionate (T3)
MF:
C10H16F2O5
EINECS No.:
1312995-182-4
Place of Origin:
Shandong, China, Shandong, China
Type:
Pharmaceutical Intermediates, Pharm Intermediates
Purity:
99.7%MIN
Brand Name:
Fousi
Model Number:
FS 95058-92-7
Application:
Pharm Intermediates
Appearance:
Powder, Powder
Product name:
propionate (T3)
CAS:
95058-92-7
Manufacturer:
fousichem
Usage:
Pharm Intermediates
color:
white
Shelf Life:
3-years
Packaging&Delivery
Packaging Details
25 KGS/Drum,5KGS/Tin, 10 KGS/Carton
Port
QINGDAO ,SHANGHAI,TIANJIN
Lead Time:
Quantity(Kilograms) 1 - 1000 >1000
Est. Time(days) 10 To be negotiated

Property

CAS No.: 95058-92-7 Formula: C10H16F2O5 Molecular Weight: 254.22800

Description

Intermediate in the preparation of ribose sugar derivatives.

Basic Info

Chemical Name	Ethyl (3R,S)-2,2-difluoro-3-hydroxy-3-(2,2-dimethyldioxolan-4-yl)propionate
Synonyms	ethyl (3R,4R)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-difluoro-3-hydroxypropanoate; Ethyl(3RS)-2,2-Difluoro-3-(2,2-Dimethylioxolan-4-yl)Propionate; Ethyl(3R,S)-2,2-difluoro-3-hydroxy-3-(2,2-dimethyldioxolan-4-yl)propionate; ethyl (R)-2,2-difluoro-3-hydroxy-3-((R)-2,2-dimethyl-[1,3]dioxoran-4-yl)propionate; ethyl 2,2-difluoro-3-hydroxy-3-(2,2-dimethyl-[1,3]dioxolan-4-yl)propionate; 2-DEOXY-2,2-DIFLUORO-4,5-O-(1-METHYLETHYLIDENE)-D-ERYTHROPENTONIC ACID ETHYL ESTER; D-ERYTHRO-PENTONIC ACID,2-DEOXY-2,2-DIFLUORO-4,5-O-(1-METHYLETHYLIDENE)-,ETHYL ESTER; ethyl (D-erythro)-3-(hydroxy)-2,2-difluoro-3-(2,2-dimethyldioxalane-4-yl)propionate; (R)-ethyl 3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-difluoro-3-hydroxypropanoate; 2-Deoxy-2,2-difluoro-4,5-O-isopropylidene-D-erythro-pentonic Acid Ethyl Ester; (erytro) ethyl-3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-difluoro-3-hydroxy propionate; ethyl (3R)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-difluoro-3-hydroxypropanoate; propionate (T3); ethyl 2,2-difluoro-3(R)-hydroxy-3-((R)-2,2-dimethyldioxolan-4-yl)propionate; 3-(2,2-Dimethyl[1,3]dioxolan-4-yl)-2,2-difluora-3-hydroxy-propionic acid ethyl ester; Ethyl(3RS)-2,2-Difluoro-3-(2,2-dimethyldioxolan-4-yl)propionate; D-erythro-Pentonic acid,2-deoxy-2,2-difluoro-4,5-O-(1-methylethylidene)-,ethyl ester (9CI);
CAS No.	95058-92-7
Molecular Formula	C10H16F2O5
Molecular Weight	254.22800
PSA	64.99000
LogP	0.69720

Properties

Density	1.232g/cm3
Boiling Point	338.388ºC at 760 mmHg
Flash Point	158.451ºC
Refractive Index	1.428

Safety Info

HS Code	2942000000

Synthesis Route

Ethyl Bromodifluoroacetate+(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde→Ethyl (3R,S)-2,2-difluoro-3-hydroxy-3-(2,2-dimethyldioxolan-4-yl)propionate
ethyl (D-erythro)-3-(4-chlorophenylcarbamoyloxy)-2,2-difluoro-3-(2,2-dimethyl-dioxalane-4-yl)propionate→1,1-diethyloxy-3-(4-chlorophenyl)urea+Ethyl (3R,S)-2,2-difluoro-3-hydroxy-3-(2,2-dimethyldioxolan-4-yl)propionate
Ethyl Bromodifluoroacetate+(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde→Ethyl (3R,S)-2,2-difluoro-3-hydroxy-3-(2,2-dimethyldioxolan-4-yl)propionate+ethyl (3S)-3-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-difluoro-3-hydroxypropanoate

Precursor

ethyl (D-erythro)-3-(4-chlorophenylcarbamoyloxy)-2,2-difluoro-3-(2,2-dimethyl-dioxalane-4-yl)propionate
Ethyl Bromodifluoroacetate
(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde

Downstream Product

Ethyl 3-O-benzoyl-2-deoxy-2,2-difluoro-4,5-O-isopropylidene-D-ery thro-pentonate

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