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esomeprazole

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Origin: China

Cas No: 119141-88-7

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 119141-88-7 Formula: C17H19N3O3S Molecular Weight: 345.41600

    Description

    Esomeprazole sold under the brand name Nexium among others, is a proton pump inhibitor which reduces stomach acid. It is used in the treatment of dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, and Zollinger-Ellison syndrome.
    It decreases secretion of acid through inhibition of the H+/K+-ATPase in the parietal cells of the stomach. By inhibiting the functioning of this transporter, the drug prevents formation of stomach acid.
    Esomeprazole is the (S)-(−)-enantiomer of omeprazole. Esomeprazole is currently sold over the counter in the US and the UK.

    Basic Info

    Chemical Name esomeprazole
    Synonyms

    S-enantiomer of omeprazole;
    esomeprazolum;
    (-)-Omeprazole;
    Esomeprazole (INN);
    (S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole;
    [14C]-(-)-Omeprazole;
    (S)-6-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole;
    Esomeprazole;
    (S)-(-)-omeprazole;
    esomeprazol;
    (S)-Esomeprazole;
    UNII-N3PA6559FT;
    6-methoxy-2-[(S)-(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole;

    CAS No. 119141-88-7
    Molecular Formula C17H19N3O3S
    Molecular Weight 345.41600
    PSA 96.31000
    LogP 3.76540

    Properties

    Density 1.37g/cm3
    Boiling Point 600ºC at 760mmHg
    Flash Point 316.7ºC
    Refractive Index 1.669
    Vapor Pressure 0mmHg at 25°C

    Safety Info

    HS Code 2933990090

    Synthesis Route

    6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfanyl]-1H-benzimidazole→(R)-omeprazole+esomeprazole
    5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole→(R)-omeprazole+esomeprazole
    6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfanyl]-1H-benzimidazole→esomeprazole

    Precursor

    6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfanyl]-1H-benzimidazole
    D(+)-10-Camphorsulfonyl chloride
    4-methoxy-2,3,5-trimethylpyridine
    (-)-menthyl (S)-5-methoxy-2-benzimidazolylsulphinate

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