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droxidopa

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Origin: China

Cas No: 23651-95-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 23651-95-8 Formula: C9H11NO5 Molecular Weight: 213.18700

    Description

    Droxidopa (INN; trade name Northera; also known as L-DOPS, L-threo-dihydroxyphenylserine, L-threo-DOPS and SM-5688) is a synthetic amino acid precursor which acts as a prodrug to the neurotransmitter norepinephrine (noradrenaline). Unlike norepinephrine, droxidopa is capable of crossing the protective blood–brain barrier (BBB).

    Basic Info

    Chemical Name droxidopa
    Synonyms

    DL-DOPS;
    DL-threo-Dihydroxyphenylserine;
    L-DOPS;
    3-dihydroxy-betthreo-dl-tyrosin;
    (2S,3R)-3-(3,4-Dihydroxyphenyl)-2-amino-3-hydroxypropanoic acid;
    3-dihydroxy-dl-tyrosinethreo-bet;
    DROXIDOPA;
    (2S,3R)-2-Amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropionic Acid;
    (2S,3R)-2-Amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid;
    DL-THREO-DOPS;
    L-threo-3,4-Dihydroxyphenylserine;
    Droxidopa L-threo 3,4-Dihydroxyphenylserine;
    DL-threo-Droxidopa;

    CAS No. 23651-95-8
    Molecular Formula C9H11NO5
    Molecular Weight 213.18700
    PSA 124.01000
    LogP 0.24340

    Properties

    Density 1.608g/cm3
    Boiling Point 549.8ºC at 760mmHg
    Flash Point 286.3ºC
    Refractive Index 1.692
    Vapor Pressure 6.39E-13mmHg at 25°C

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Oral LD50 - Lethal dose, 50 percent kill Rodent - rat >10 gm/kg 1.Details of toxic effects not reported other than lethal dose value
    Subcutaneous LD50 - Lethal dose, 50 percent kill Rodent - rat 84 mg/kg 1.Details of toxic effects not reported other than lethal dose value
    Intravenous LD50 - Lethal dose, 50 percent kill Rodent - rat 16 mg/kg 1.Behavioral-somnolence (general depressed activity)
    2.Behavioral-ataxia
    3.Lungs, Thorax, or Respiration-other changes

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