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diphenidol

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Origin: China

Cas No: 972-02-1

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 972-02-1 Formula: C21H27NO Molecular Weight: 309.44500

Description

Diphenidol is a muscarinic antagonist employed as an antiemetic and as an antivertigo agent. It is not marketed in the United States or Canada. - Although the mechanism of action of Diphenidol on the vestibular system has not yet been elucidated, it exerts an anticholinergic effect due to interactions with mACh receptors, particularly M1, M2, M3 and M4. Hence, its actions may take place at the vestibular nuclei, where a significant excitatory input is mediated by ACh receptors, and also at the vestibular periphery where mACh receptors are expressed at efferent synapses. Recently, a series of selective mACh-receptor antagonists based on the Diphenidol molecule has been synthesized, but they have not yet been the subject of clinical trials* .

Basic Info

Chemical Name	diphenidol
Synonyms	defenidol; Difenidolum; 1,1-diphenyl-4-piperidin-1-ylbutan-1-ol; Difenidolo [DCIT]; Difenidol; Cephadol; Difenidolo; Diphenidol; Nometic; 1,1-diphenyl-4-piperidylbutanol; 1,1-diphenyl-4-piperidin-1-yl-butan-1-ol; Avomol; Vontrol;
CAS No.	972-02-1
Molecular Formula	C21H27NO
Molecular Weight	309.44500
PSA	23.47000
LogP	4.12650

Properties

Density	1.066 g/cm3
Boiling Point	473.3ºC at 760 mmHg
Melting Point	105ºC
Flash Point	233.5ºC

Safety Info

HS Code	2933399090

Synthesis Route

Piperidine+carbon monoxide→diphenidol
Benzophenone→diphenidol
Piperidine+4-hydroxy-4,4-diphenylbutyl chloride→diphenidol

GC Analysis

Column type	Active phase	Temperature (°C)	Retention Index (I)	Temperature Control Method
Packed	SE-30	-	2390.	temperature ramp
Capillary	Polydimethyl siloxanes	-	2384.	custom temperature program
Other	Methyl Silicone	-	2384.	custom temperature program

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - rat	815 mg/kg	1.Details of toxic effects not reported other than lethal dose value
Subcutaneous	LD50 - Lethal dose, 50 percent kill	Rodent - rat	304 mg/kg	1.Details of toxic effects not reported other than lethal dose value
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - mouse	450 mg/kg	1.Details of toxic effects not reported other than lethal dose value