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diphenidol

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начало: Китай

Кас Но: 972-02-1

Спецификация: 99%наименьший

минимальный объем заказа: 1 /kg

снабженческая способность: 100 mt/month

опережающий период: OEM 7 дней, пятно 3 дня

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  • Характеристики продукции
  • Описание продукта

  • Property

    CAS No.: 972-02-1 Formula: C21H27NO Molecular Weight: 309.44500

    Description

    Diphenidol is a muscarinic antagonist employed as an antiemetic and as an antivertigo agent. It is not marketed in the United States or Canada. - Although the mechanism of action of Diphenidol on the vestibular system has not yet been elucidated, it exerts an anticholinergic effect due to interactions with mACh receptors, particularly M1, M2, M3 and M4. Hence, its actions may take place at the vestibular nuclei, where a significant excitatory input is mediated by ACh receptors, and also at the vestibular periphery where mACh receptors are expressed at efferent synapses. Recently, a series of selective mACh-receptor antagonists based on the Diphenidol molecule has been synthesized, but they have not yet been the subject of clinical trials* .

    Basic Info

    Chemical Name diphenidol
    Synonyms

    defenidol;
    Difenidolum;
    1,1-diphenyl-4-piperidin-1-ylbutan-1-ol;
    Difenidolo [DCIT];
    Difenidol;
    Cephadol;
    Difenidolo;
    Diphenidol;
    Nometic;
    1,1-diphenyl-4-piperidylbutanol;
    1,1-diphenyl-4-piperidin-1-yl-butan-1-ol;
    Avomol;
    Vontrol;

    CAS No. 972-02-1
    Molecular Formula C21H27NO
    Molecular Weight 309.44500
    PSA 23.47000
    LogP 4.12650

    Properties

    Density 1.066 g/cm3
    Boiling Point 473.3ºC at 760 mmHg
    Melting Point 105ºC
    Flash Point 233.5ºC

    Safety Info

    HS Code 2933399090

    Synthesis Route

    Piperidine+carbon monoxide→diphenidol
    Benzophenone→diphenidol
    Piperidine+4-hydroxy-4,4-diphenylbutyl chloride→diphenidol

    GC Analysis

    Column type Active phase Temperature (°C) Retention Index (I) Temperature Control Method
    Packed SE-30 - 2390. temperature ramp
    Capillary Polydimethyl siloxanes - 2384. custom temperature program
    Other Methyl Silicone - 2384. custom temperature program

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Oral LD50 - Lethal dose, 50 percent kill Rodent - rat 815 mg/kg 1.Details of toxic effects not reported other than lethal dose value
    Subcutaneous LD50 - Lethal dose, 50 percent kill Rodent - rat 304 mg/kg 1.Details of toxic effects not reported other than lethal dose value
    Oral LD50 - Lethal dose, 50 percent kill Rodent - mouse 450 mg/kg 1.Details of toxic effects not reported other than lethal dose value

    Precursor

    α-ethenyl-α-phenyl-benzenemethanol
    Piperidine
    Benzophenone
    4-hydroxy-4,4-diphenylbutyl chloride

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