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dihydrofolic acid

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Origin: China

Cas No: 4033-27-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 4033-27-6 Formula: C19H21N7O6 Molecular Weight: 443.41300

    Description

    Dihydrofolic acid (conjugate base dihydrofolate) (DHF) is a folic acid (vitamin B9) derivative which is converted to tetrahydrofolic acid by dihydrofolate reductase. Since tetrahydrofolate is needed to make both purines and pyrimidines, which are building blocks of DNA and RNA, dihydrofolate reductase is targeted by various drugs to prevent nucleic acid synthesis.

    Basic Info

    Chemical Name dihydrofolic acid
    Synonyms

    7,8-Dihydropteroyl-L-glutamic acid Dihydropteroyl-L-glutamic acid;
    DIHYDROFOLIC ACID;
    7,8-Dihydrofolic acid;

    CAS No. 4033-27-6
    Molecular Formula C19H21N7O6
    Molecular Weight 443.41300
    PSA 211.89000
    LogP 0.62870

    Properties

    Density 1.69g/cm3
    Refractive Index 1.762
    Storage Condition -20ºC

    Safety Info

    Safety Statements S26; S36
    Risk Statements R36/37/38
    Hazard Codes Xi
    Symbol GHS07
    Signal Word Warning
    Hazard Declaration H315; H319; H335
    Caution Statement P261; P305 + P351 + P338

    Synthesis Route

    Folic acid→dihydrofolic acid
    →dihydrofolic acid
    2-amino-6[[2'(R)-(benzylamino)-3'-hydroxypropyl]amino]-5-nitro-4(3H)-pyrimidinone→dihydrofolic acid

    Precursor

    2-amino-6[[2'(R)-(benzylamino)-3'-hydroxypropyl]amino]-5-nitro-4(3H)-pyrimidinone
    2-amino-6-[[2'(R)-[N-(tert-butoxycarbonyl)-N-benzylamino]-3'-hydroxypropyl]amino]-5-nitro-4(3H)-pyrimidinone
    Folic acid

    Downstream Product

    5,6,7,8-tetrahydrofolic acid

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