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digitoxin

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начало: Китай

Кас Но: 71-63-6

Спецификация: 99%наименьший

минимальный объем заказа: 1 /kg

снабженческая способность: 100 mt/month

опережающий период: OEM 7 дней, пятно 3 дня

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Характеристики продукции
Описание продукта

Property

CAS No.: 71-63-6 Formula: C41H64O13 Molecular Weight: 764.93900

Description

Digitoxin is a cardiac glycoside. It is similar in structure and effects to digoxin (though the effects are longer-lasting). Unlike digoxin (which is eliminated from the body via the kidneys), it is eliminated via the liver, so could be used in patients with poor or erratic kidney function. However, it is now rarely used in current Western medical practice. While several controlled trials have shown digoxin to be effective in a proportion of patients treated for heart failure, the evidence base for digitoxin is not as strong, although it is presumed to be similarly effective.

Basic Info

Chemical Name	digitoxin
Synonyms	digicor; tridigitoxosyldigitoxigenin; Ditaven; Digitrin; Cardigin; Digilong; Natigal; Myodigin; Digimed; Card-20(22)-enolide, 3-[(O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-β-D, 14-dihydroxy-; De-Tone; DIGITOXIN; [3H]-Digitoxin; Acedoxin;
CAS No.	71-63-6
Molecular Formula	C41H64O13
Molecular Weight	764.93900
PSA	182.83000
LogP	3.24730

Properties

Appearance & Physical State	WHITE POWDER
Density	1.33 g/cm3
Boiling Point	902.3ºC at 760 mmHg
Melting Point	240ºC (dec.)(lit.)
Flash Point	269.5ºC
Refractive Index	1.593
Storage Condition	Dark Room

Safety Info

RTECS	IH2275000
Hazard Class	6.1(a)
Safety Statements	S45
WGK Germany	3
Packing Group	II
RIDADR	UN 2811
Risk Statements	R23/25; R33
Hazard Codes	T
Caution Statement	P261; P301 + P310; P311
Symbol	GHS06, GHS08
Hazard Declaration	H301; H331; H373
Signal Word	Danger

Synthesis Route

digitoxigen O-[2'',6''-dideoxy-β-D-ribo-hexopyranosyl]-(1->4)-O-[3'-O-acetyl-2',6'-dideoxy-β-D-ribo-hexopyranosyl]-(1->4)-(3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranoside→digitoxin
3,4-bis-(tert-butyldimethylsilyl)-1,5-anhydro-2,6-dideoxy-D-ribo-hex-1-enitol→digitoxin
(2R,3R,4S)-4-(tert-butyldimethylsiloxy)-hex-5-yne-2,3-diol 2-benzoate ester→digitoxin

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Administration into the eye	Standard Draize test	Mammal - dog	1%/1D	-
Oral	TDLo - Lowest published toxic dose	Human - woman	400 ug/kg	1.Cardiac-EKG changes not diagnostic of specified effects 2.Gastrointestinal-nausea or vomiting
Oral	LDLo - Lowest published lethal dose	Human - man	286 ug/kg	1.Peripheral Nerve and Sensation-paresthesis 2.Cardiac-pulse rate increase, without fall in BP 3.Blood-thrombocytopenia

Precursor

(2R,3R,4S)-3-(((2S,4S,5R,6R)-4,5-bis((tert-butyldimethylsilyl)oxy)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-((tert-butyldimethylsilyl)oxy)hex-5-yn-2-ol
(2R,3R,4S)-4-(tert-butyldimethylsiloxy)-hex-5-yne-2,3-diol 2-benzoate ester
4-O-[3,4-bis-(tert-butyldimethylsilyl)-2,6-dideoxy-β-D-allopyranosyl]-3-(tert-butyldimethylsilyl)-1,5-anhydro-2,6-dideoxy-D-ribo-hex-1-entol
digitoxigen O-[2'',6''-dideoxy-β-D-ribo-hexopyranosyl]-(1->4)-O-[3'-O-acetyl-2',6'-dideoxy-β-D-ribo-hexopyranosyl]-(1->4)-(3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranoside

Downstream Product

digitoxigenin
3'''-O-acetyldigitoxin
3-[(5R,10S,13R,14S,17R)-14-hydroxy-10,13-dimethyl-3-oxo-2,4,5,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2H-furan-5-one
3-[(3S,5R,10S,13R,14S,17R)-3-[(2R,4S,5S,6R)-5-[(2S,4S,5S,6R)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyloxan-2-yl]oxy-14-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one

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