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dapagliflozin

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Origin: China

Cas No: 461432-26-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 461432-26-8 Formula: C21H25ClO6 Molecular Weight: 408.87300

    Description

    A sodium-glucose transporter 2 inhibitor.

    Basic Info

    Chemical Name dapagliflozin
    Synonyms

    [14C]-Dapagliflozin;
    (2S,3R,4R,5S,6R)-2-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol;
    D-Glucitol,1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-,(1S);
    dapaglifozin;
    Dapagliflozin;
    (2S,3R,4R,5S,6R)-2-[4-chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxymethy)tetrahydro-2H-pyran-3,4,5-triol;
    Forxiga (TN);
    (2S,3R,4R,5S,6R)-2-[4-chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol;

    CAS No. 461432-26-8
    Molecular Formula C21H25ClO6
    Molecular Weight 408.87300
    PSA 99.38000
    LogP 1.84440

    Properties

    Density 1.349
    Boiling Point 609ºC at 760mmHg
    Flash Point 322.1ºC
    Refractive Index 1.614

    Synthesis Route

    (3R,4S,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol→dapagliflozin
    α-​D-​Glucopyranoside, methyl 1-​C-​[4-​chloro-​3-​[(4-​ethoxyphenyl)​methyl]​phenyl]​-→dapagliflozin
    Glucono-δ-Lactone→dapagliflozin

    Precursor

    Glucono-δ-Lactone
    2-Chloro-5-iodobenzoic acid
    α-​D-​Glucopyranoside, methyl 1-​C-​[4-​chloro-​3-​[(4-​ethoxyphenyl)​methyl]​phenyl]​-
    (3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one

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