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dansyl chloride

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Origin: China

Cas No: 605-65-2

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

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  • Products Specification
  • Product Description
  • Quick Details

    CAS No.:
    605-65-2
    Other Names:
    -
    MF:
    C12H12ClNO2S
    EINECS No.:
    210-092-6
    Place of Origin:
    Shanghai, China
    Type:
    Pharmaceutical Intermediates
    Purity:
    99% Min
    Brand Name:
    KY CHEM
    Model Number:
    605-65-2
    Application:
    Intermediates
    Appearance:
    Yellow powder
    Colorcry:
    Yellow
    Form:
    powder
    Density:
    1.361
    M.P.:
    70-73°C
    B P:
    371.3°C
    F.P:
    178.4°C
    Refractive index:
    1.636
    Molecular Weight:
    269.75
    Lead Time:
    Promptly
    COA/MSDS:
    Available

    Packaging&Delivery

    Packaging Details
    100g/500g/1kg/5kg/10kg/25kg or as your special request.
    Port
    Shanghai Port
  • Property

    CAS No.: 605-65-2 Formula: C12H12ClNO2S Molecular Weight: 269.74700

    Description

    Dansyl chloride or 5-(DimethylAmino)Naphthalene-1-SulfonYL chloride is a reagent that reacts with primary amino groups in both aliphatic and aromatic amines to produce stable blue- or blue-green–fluorescent sulfonamide adducts. It can also be made to react with secondary amines. Dansyl chloride is widely used to modify amino acids; specifically, protein sequencing and amino acid analysis. It can also be used to label hydroxyl and carboxylic acid functional groups.
    Dansyl chloride may also be denoted DNSC. Likewise, a similar derivative, dansyl amide is known as DNSA.
    In addition, these protein-DNSC conjugates are sensitive to their immediate environment. This, in combination with their ability to accept energy (as in fluorescence resonance energy transfer) from the amino acid tryptophan, allows this labeling technique to be used in investigating protein folding and dynamics.
    The fluorescence of these sulfonamide adducts can be enhanced by adding alpha-cyclodextrin. Dansyl chloride is unstable in dimethyl sulfoxide, which should never be used to prepare solutions of the reagent.
    The extinction coefficient of dansyl derivatives are important for measuring their concentration in solution. Dansyl chloride is one of the simplest sulfonamide derivatives, so it commonly serves as a starting reagent for the production of other derivatives. Exotic derivatives may have very different extinction coefficients, but others, such as dansyl amide, are similar to dansyl chloride in absorption and fluorescence characteristics. But even for dansyl chloride, there are a variety of extinction coefficient values that have been reported. Some of the values are used to estimate the extent of success in attempts to conjugate the dye to a protein. Other values may be used to determine a precise concentration of a stock solution. See the table below for specific values and their uses.
    For all of the studies below, the absorption value is always taken at the maximum that appears between 310nm and 350nm. The peak is broad, so the measurement is not very sensitive. However, trivial errors due to wavelength calibration of the spectrophotometer can be avoided by taking the value at the maximum instead of strictly using 330nm.

    Basic Info

    Chemical Name dansyl chloride
    Synonyms

    Dansyl Chloride;
    1-Naphthalenesulfonyl chloride, 5-(dimethylamino)-;
    5-(dimethylamino)naphthalene-1-sulfonyl chloride;

    CAS No. 605-65-2
    Molecular Formula C12H12ClNO2S
    Molecular Weight 269.74700
    PSA 45.76000
    LogP 3.91410

    Properties

    Appearance & Physical State yellow fine crystalline powder
    Density 1.361 g/cm3
    Boiling Point 371.3ºC at 760 mmHg
    Melting Point 70-73ºC
    Flash Point 178.4ºC
    Refractive Index 1.636
    Stability Stable under normal temperatures and pressures.
    Storage Condition 2-8ºC

    Safety Info

    RTECS QK3688000
    Hazard Class 8
    Safety Statements S26-S36/37/39-S45
    HS Code 29214980
    WGK Germany 3
    Packing Group III
    RIDADR UN 3261
    Risk Statements R34
    Hazard Codes C
    Hazard Declaration H314
    Caution Statement P280; P305 + P351 + P338; P310
    Symbol GHS05
    Signal Word Danger

    Synthesis Route

    5-(dimethylamino)naphthalene-1-sulfonic aciddansyl chloride
    5-Aminonaphthalene-1-sulfonic aciddansyl chloride

    Precursor

    5-Aminonaphthalene-1-sulfonic acid
    5-(dimethylamino)naphthalene-1-sulfonic acid

    Downstream Product

    5-(dimethylamino)-N-(4-hydroxybutyl)naphthalene-1-sulfonamide
    (2S)-2-[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]pentanedioic acid
    DANSYL-L-GLUTAMINE
    Dansyl Ethylenediamine

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