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Dalcetrapib

Name: Dalcetrapib
Brand: Globalchemmall
SKU: g

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Origin: China

Cas No: 211513-37-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property
CAS No.: 211513-37-0 Formula: C23H35NO2S Molecular Weight: 389.59500

Description
Dalcetrapib or JTT-705 is a CETP inhibitor which was being developed by Hoffmann–La Roche until May 2012. The drug was aimed at raising the blood levels of "good cholesterol" (cholesterol carried in HDL particles, aka HDL-C). Prevailing observations indicate that high HDL levels correlate with better overall cardiovascular health, though it remains unclear whether raising HDL levels consequently leads to an increase in cardiovascular health.
A 24-week clinical trial showed that dalcetrapib did increase HDL-C levels, supporting the agent's desired effect. Further, the dal-PLAQUE phase IIb trial found evidence of plaque reduction. Plaque reduction is an anticipated observation following an increase in HDL.; As of 2010[update] five phase II trials had started and there was no evidence of the raised blood pressure seen with torcetrapib.
dal-VESSEL phase IIb trial found no evidence of flow-mediated dilatation improvement. A 17% increase of Lp-PLA2 mass level was noted. Lp-PLA2 is associated with coronary heart disease and stroke.; dal-OUTCOMES phase III trial passed its first interim review in July, 2011, however, development was halted on May 7, 2012 “due to a lack of clinically meaningful efficacy.”.
The results of dal-OUTCOMES III were published in November, 2012.

Basic Info

Chemical Name Dalcetrapib

Synonyms
JTT-705;
Unii-3D050liq3h;

CAS No. 211513-37-0

Molecular Formula C23H35NO2S

Molecular Weight 389.59500

PSA 71.47000

LogP 6.74960

Properties

Density 1.066 g/cm3

Boiling Point 528.912ºC at 760 mmHg

Flash Point 273.676ºC