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D-penicillamine

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Origin: China

Cas No: 52-67-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 52-67-5 Formula: C5H11NO2S Molecular Weight: 149.21100

    Description

    Penicillamine, sold under the trade names of Cuprimine, Cuprenyl and Depen, is a medication of the chelator class. It is D-penicillamine, as L-penicillamine is toxic (it inhibits the action of pyridoxine, also known as vitamin B6). It is an α-amino acid metabolite of penicillin, although it has no antibiotic properties.
    It is on the World Health Organization's List of Essential Medicines, the most important medication needed in a basic health system.

    Basic Info

    Chemical Name D-penicillamine
    Synonyms

    D-Penicillamine;
    Sufirtan;
    D(-)-Penicillamine;
    Cuprimin;
    D-β,β-Dimethylcysteine;
    D-Valine, 3-mercapto-;
    H-D-Pen-OH;
    Perdolat;
    Cuprenil;
    3,3-Dimethyl-D(-)-cysteine;
    Artamine;
    D-β-Mercaptovaline;
    Penicillamine;
    Depen;
    usan;
    (2S)-2-amino-3-methyl-3-sulfanylbutanoic acid;
    emtexate;
    d-valin;
    3,3-Dimethyl-D-cysteine,3-Mercapto-D-valine,D-(−)-2-Amino-3-mercapto-3-methylbutanoic acid;
    Depamine;
    3-mercapto-D-valine;

    CAS No. 52-67-5
    Molecular Formula C5H11NO2S
    Molecular Weight 149.21100
    PSA 102.12000
    LogP 0.80700

    Properties

    Appearance & Physical State white powder
    Density 1.204g/cm3
    Boiling Point 251.8ºC at 760mmHg
    Melting Point 212ºC
    Flash Point 106.1ºC
    Refractive Index -63 ° (C=1, 1mol/L NaOH)
    Water Solubility 11.1 g/100 mL (20 ºC)
    Stability Stable. Incompatible with strong oxidizing agents.
    Storage Condition 2-8ºC

    Safety Info

    RTECS YV9425000
    Safety Statements S24/25
    HS Code 2930909090
    WGK Germany 2
    Risk Statements R36/37/38
    Hazard Codes Xi; T; Xn
    Signal Word Warning
    Symbol GHS07
    Hazard Declaration H315; H319; H335
    Caution Statement P261; P305 + P351 + P338

    Synthesis Route

    2-Aminobenzenethiol→D-penicillamine
    o-toluidine→D-penicillamine
    p-toluidine→D-penicillamine

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Oral TDLo - Lowest published toxic dose Human - woman 900 mg/kg/26W-I 1.Skin and Appendages-dermatitis, other (after systemic exposure)
    Oral TDLo - Lowest published toxic dose Human - woman 650 gm/kg/81W-I 1.Behavioral-muscle weakness
    2.Musculoskeletal-other changes
    Oral TDLo - Lowest published toxic dose Human - woman 112 mg/kg/1W-I 1.Blood-agranulocytosis
    2.Skin and Appendages-dermatitis, other (after systemic exposure)
    3.Nutritional and Gross Metabolic-body temperature increase

    Precursor

    o-toluidine
    p-toluidine
    2-Aminobenzenethiol
    benzylpenicillin potassium

    Downstream Product

    (2S)-2-amino-3-methyl-3-tritylsulfanylbutanoic acid
    (2R)-3-methyl-2-[(1-methylazepan-2-ylidene)amino]-3-sulfanylbutanoic acid
    (2R)-2-(3,4-dihydro-2H-pyrrol-5-ylamino)-3-methyl-3-sulfanylbutanoic acid
    (2R)-3-methyl-2-[(1-methylpiperidin-2-ylidene)amino]-3-sulfanylbutanoic acid

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