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D-4-hydroxyphenylglycine

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Origin: China

Cas No: 22818-40-2

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
22818-40-2
Other Names:
4-HYDROXY-D-PHENYLGLYCINE
MF:
C8H10N2O
EINECS No.:
245-247-7
Place of Origin:
Jiangsu, China
Type:
Pharmaceutical Intermediates
Purity:
98%
Brand Name:
YALONG
Model Number:
22818-40-2
Application:
Used as pharmaceutical intermediates
Appearance:
white or almost white crystalline powder
Molecular weight::
150.1778
Packaging&Delivery
Packaging Details
25KG/Fiber cans
Port
any port of china

Property

CAS No.: 22818-40-2 Formula: C8H9NO3 Molecular Weight: 167.16200

Description

4-Hydroxy-D-(-)-2-phenylglycine is an compound used mainly for the synthetic preparation of β-lactam antibiotics.

Basic Info

Chemical Name	D-4-hydroxyphenylglycine
Synonyms	(R)-2-(4-Hydroxyphenyl)glycine; (D)-(-)-Alfa-4-hydroxyphenyl glycine; D-N-(4-Hydroxyphenyl)glycine; (R)-2-Amino-2-(4-hydroxyphenyl)acetic acid; 2-(4-Hydroxyphenyl)-D-glycine; (R)-para-hydroxyphenylglycine; H-D-Phg(4-OH)-OH; (2R)-2-amino-2-(4-hydroxyphenyl)acetic acid; D(-)-2-amino-(4-hydroxyphenyl)acetic acid; D(-)-4-Hydroxyphenylglycine; 4-Hydroxy-D-phenylglycine; 4-Hydroxy-D-(-)-2-phenylglycine; (2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid,4-Hydroxy-D-phenylglycine; (2R)-2-Amino-2-(4; (R)-(-)-2-Amino-2-(4-hydroxyphenyl)acetic acid; D(-)-2-(4-hydroxyphenyl)glycine; D-(-)-2-(4-Hydroxyphenyl)glycine; (2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid,4-Hydroxy-D-phenylglycine,Cefadroxyl impurity A;
CAS No.	22818-40-2
Molecular Formula	C8H9NO3
Molecular Weight	167.16200
PSA	83.55000
LogP	1.17690

Properties

Appearance & Physical State	White to off-white crystalline powder
Density	1.396
Melting Point	240ºC
Flash Point	223.7ºC
Refractive Index	-158 ° (C=1, 1mol/L HCl)
Water Solubility	5 g/L (20 ºC)
Stability	Stable under normal temperatures and pressures.
Storage Condition	Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances.
Vapor Pressure	0.000272mmHg at 25°C

Safety Info

Safety Statements	S24/25
HS Code	29225000
WGK Germany	3
Risk Statements	R36/37/38
Hazard Codes	Xi

Synthesis Route

Methanol+4-((3R,5S)-2-oxo-5-phenyl-morpholin-3-yl)phenyl acetate→D-4-hydroxyphenylglycine+(R)-Methyl 2-amino-2-(4-hydroxyphenyl)acetate
p-hydroxy-phenylglycine methyl ester→D-4-hydroxyphenylglycine+(2S)-2-amino-2-(4-hydroxyphenyl)acetic acid
2-amino-2-(4-hydroxyphenyl)acetic acid→D-4-hydroxyphenylglycine+(2S)-2-amino-2-(4-hydroxyphenyl)acetic acid

Precursor

4-((3R,5S)-2-oxo-5-phenyl-morpholin-3-yl)phenyl acetate
2-amino-2-(4-hydroxyphenyl)acetic acid
p-hydroxy-phenylglycine methyl ester
(2R)-2-(4-hydroxyphenyl)-2-[(2-phenylacetyl)amino]acetic acid

Downstream Product

(2R)-2-(4-hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]acetic acid
D-(3,4-DIHYDROXY) A-PHENYLGLYCINE
(R)-Methyl 2-amino-2-(4-hydroxyphenyl)acetate
methyl (2R)-2-amino-2-(4-hydroxyphenyl)acetate,hydrochloride

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