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cytisine

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Origin: China

Cas No: 485-35-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

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Products Specification
Product Description

Property

CAS No.: 485-35-8 Formula: C11H14N2O Molecular Weight: 190.24200

Description

Cytisine, also known as baptitoxine and sophorine, is an alkaloid that occurs naturally in several plant genera, such as Laburnum and Cytisus of the family Fabaceae. It has been used medically to help with smoking cessation. Its molecular structure has some similarity to that of nicotine and it has similar pharmacological effects. Like varenicline, cytisine is a partial agonist of nicotinic acetylcholine receptors (nAChRs). Cytisine has a short half-life of 4.8 hours, and is rapidly eliminated from the body. The use of cytisine for smoking cessation remains relatively unknown outside Eastern Europe.

Basic Info

Chemical Name	cytisine
Synonyms	Sophorine; Laburnin; (-)-Cytisine; CYTISINE; Baptitoxin; (1R,5S)-3,4,5,6-Tetrahydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocin-8(2H)-one; Cytiton; Tabex; Cytitone; Baptitoxine; Tsitafat；Lupinidine; 8H-Pyrido-[1,2-a][1,5]diazocin-8-one, 1,2,3,4,5,6-hexahydro-1,5-methano-;
CAS No.	485-35-8
Molecular Formula	C11H14N2O
Molecular Weight	190.24200
PSA	34.03000
LogP	0.88380

Properties

Appearance & Physical State	Off-White to Tan Crystalline Solid
Density	1.24 g/cm3
Boiling Point	218ºC (2 mmHg)
Melting Point	154-156ºC
Flash Point	203.6ºC
Storage Condition	Store at RT
Vapor Pressure	4.95E-07mmHg at 25°C

Safety Info

RTECS	HA4025000
Hazard Class	6.1(b)
Safety Statements	S26-S28-S36/37-S45
HS Code	2933990090
WGK Germany	3
Packing Group	III
RIDADR	UN 2811
Risk Statements	R25; R36/37/38
Hazard Codes	T

Synthesis Route

(6R,7R,9R)-(-)-N-benzyloxycarbonyl-cytisine→cytisine
(3S,5R)-(+)-3-acetoxymethyl-5-formyl-1-piperidine-1-carbvoxylic acid benzyl ester→cytisine
(3S,5R)-3-acetoxymethyl-5-hydroxymethylpiperidine-1-carboxylic acid benzyl ester→cytisine

Precursor

(3S,5R)-3-acetoxymethyl-5-hydroxymethylpiperidine-1-carboxylic acid benzyl ester
(6R,7R,9R)-(-)-N-benzyloxycarbonyl-cytisine
(3S,5R,1'S)-(-)-3-acetoxymethyl-5-(1'-hydroxybut-3'-enyl)-1-piperidine-1-carboxylic acid benzyl ester
(3S,5R,1'R)-(-)-3-acetoxymethyl-5-(1'-azidobut-3'-enyl)-1-piperidine-1-carboxylic acid benzyl ester

Downstream Product

cytisine
12-(3-Aminopropyl)-cytisine
N-Methylcytisine

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