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Cyamemazine

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Origin: China

Cas No: 3546-03-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 3546-03-0 Formula: C19H21N3S Molecular Weight: 323.45500

Description

Cyamemazine (Tercian), also known as cyamepromazine, is a typical antipsychotic drug of the phenothiazine class which was introduced by Theraplix in France in 1972 and later in Portugal as well. It is used for the treatment of schizophrenia and, especially, for psychosis-associated anxiety, due to its unique anxiolytic efficacy.
Cyamemazine differs from other phenothiazine neuroleptics in that aside from the usual profile of dopamine, α1-adrenergic, H1, and mACh receptor antagonism, it additionally produces potent blockade of several serotonin receptors, including 5-HT2A, 5-HT2C, and 5-HT7. These actions have been implicated in cyamemazine's anxiolytic effects (5-HT2C) and lack of extrapyramidal side effects (5-HT2A), and despite being classified as a typical, it actually behaves like an atypical antipsychotic.

Basic Info

Chemical Name	Cyamemazine
Synonyms	10-[3-(dimethylamino)-2-methylpropyl]phenothiazine-2-carbonitrile; 10H-Phenothiazine-2-carbonitrile, 10-[3-(dimethylamino)-2-methylpropyl]-;
CAS No.	3546-03-0
Molecular Formula	C19H21N3S
Molecular Weight	323.45500
PSA	55.57000
LogP	4.42368

Properties

Density	1.21 g/cm3
Boiling Point	479ºC at 760mmHg
Flash Point	243.5ºC
Refractive Index	1.654

Safety Info

HS Code	2934300000
Signal Word	Warning
Symbol	GHS09
Hazard Declaration	H410
Caution Statement	P273; P501

Synthesis Route

cyamemazine N-oxide→10-[2-methyl-3-(methylamino)propyl]phenothiazine-2-carbonitrile+Cyamemazine
10H-Phenothiazine-2-carboxylic acid→Cyamemazine
10H-phenothiazine-2-carboxylic acid amide→Cyamemazine

Precursor

10H-phenothiazine-2-carboxylic acid amide
2-Chlorophenothiazine
10H-Phenothiazine-2-carbonitrile
cyamemazine N-oxide

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