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clarithromycin

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Origin: China

Cas No: 81103-11-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Product Name: Clarithromycin

    Synonyms: Clarithromycine; Clathromycin, Clarithromycinum

    Chemical name: 6-O-Methylerythromycin. 

    CAS Number: 81103-11-9

    Forms: Clarithromycin Granular, Clarithromycin Granule; Clarithromycin Micronized Powder, Clarithromycin Micro Powder

    Characteristics: White to off-white crystalline powder. 

    Assay: 94% Min

    Formula: C38H69NO13

    Density: 1.18 g/cm3

    Melting Range: 217-220ºC

    Package information: 25Kgs/Drum;  5KG/Drum, 10KG/Drum

    KEY Words: Clarithromycin, Clarithromycine, Clarithromycinum Powder API, Raw Material

    Storage: Store only in original container. Keep container tightly closed. 

    Quality standard: CP/  USP/  IP2014

     

    Description: 

    Clarithromycin is a semisynthetic macrolide anti-biotic. It derives from erythromycin. 

    Clarithromycin will inhibit bacteria’s protein synthesis. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.

    Clarithromycin is an antibiotic used to treat various bacterial infections. For example the infections of  includes strep throat, pneumonia, skin, H. pylori infection, and Lyme disease. Clarithromycin can be taken orally as a pill or liquid.

    Developed in 1980. Clarithromycin is on the WHO's List of Essential Medicines, it is the most important medications needed in a basic health system. Clarithromycin is available as a generic medication. Clarithromycin is made from erythromycin, and it have a chemical name 6-O-methylerythromycin.

    Clarithromycin Powder API, Raw Material is a semi-synthetic macrolide antibiotic, which is chemically related to erythromycin and azithromycin. Clarithromycin is effective against a wide variety of bacteria, such as Haemophilus influenzae, mycobacterium avium, Streptococcus pneumoniae, etc. Like all macrolide antibiotics, Clarithromycin Powder API, Raw Material will interfere bacteria’s ability to make proteins, thus the growth will be stopped. Due to the differences in the way proteins are made in bacteria and humans, Clarithromycin will not interfere with production of proteins in humans. Clarithromycin Powder API, Raw Material derived from Streptomyces bacteria. It will inhibit protein synthesis by bacteria at the 50S ribosome. They are characterized by a macrocyclic ring (a large ring molecule with many functional groups bonded to it) and a large lactone ring in the molecular structure. Clarithromycin is usually used to produce medicines which is indicated for tract, skin, and genitourinary infections.

    Clarithromycin Inhibits Myometrial Contractions in Isolated Human Myometrium Independent of Stimulus.

     

    Classification:

    Clarithromycin Powder API, Raw Material will be classified as Antibacterial, Antibiotic, Anti-infective Agent, Gastrointestinal Agent, Macrolide.

    Certificate of Analysis of Clarithromycin

    Items

    Specifications

    Results

    Appearance

    Clarithromycin

    White to almost white crystalline powder

    white crystalline powder

    Solubility

    Clarithromycin

    Soluble in acetone;slightly soluble in dehydrated alcohol,in methanol,

    and in acctonitrile,and in phosphate butter at PH values of 2 to5;

    practically insoluble in water

    Conforms

    Identification

    Clarithromycin

    IR:conforms to the spectrum of clarithromycin RS

    Conforms

    Specific optical  rotation

    -94.--102.(anhydrous substance,1

    0mg/ml methylene chloride)

    -98.

    Sulphated ash

    ≤ 0.2%

    <0.01%

    Appearance of solution

    Clear or not more opalescent than reference suspension II

     and not more intensely coloured than reference solutionY7 

    Conforms

    Crystallinity 

    Meet the requirements

    Conforms 

    pH

    8.0-10.0

    8.7

    Water 

    ≤ 2.0%

    0.35%

    Related substances

    (1)any single impurity

    ≤ 1.0%

    0.65%

    (2)any impurities

     greater than 0.4%

    not more than 4 impurities

    1

    (3)total impurities

    ≤ 3.5%

    2.0%

    Heavy metals

    ≤ 0.002%

    2.0%

    Residul solvents

         Ethanol ≤ 5000ppm

    Not detected

    Pyridine≤220ppm

    Not detected

    Assay (on dried basis )

    Clarithromycin

    96.0% ~ 102.0%(anhydrous substance)

    97.3%

    Conclusion

    It complies with USP38 standard.
  •  

    Property

    CAS No.: 81103-11-9 Formula: C38H69NO13 Molecular Weight: 747.95300
     

    Description

    Clarithromycin, sold under the brand name Biaxin, is an antibiotic used to treat various bacterial infections. This includes strep throat, pneumonia, skin infections, H. pylori infection, and Lyme disease, among others. Clarithromycin can be taken by mouth as a pill or liquid.
    Common side effects include nausea, vomiting, headaches, and diarrhea. Severe allergic reactions are rare. Liver problems have been reported. It may cause harm if taken during pregnancy. It is in the macrolide class and works by stopping the making of protein by some bacteria.
    Clarithromycin was developed in 1980. It is on the World Health Organization's List of Essential Medicines the most important medications needed in a basic health system. Clarithromycin is available as a generic medication. The wholesale cost in the developing world is between 0.13 and 0.79 USD per dose. In the United States it is moderately expensive at 50 to 100 USD for a course of treatment. It is made from erythromycin and is chemically known as 6-O-methylerythromycin.
     

    Basic Info

    Chemical Name clarithromycin
    Synonyms

    BIAXIN;
    Claris;
    Claric;
    Naxy;
    Clarithromycin;
    Kladd;
    Zeclar;
    klacid;
    Veclam;
    TE-031;
    te-03;

    CAS No. 81103-11-9
    Molecular Formula C38H69NO13
    Molecular Weight 747.95300
    PSA 182.91000
    LogP 2.43970
     

    Properties

    Appearance & Physical State white to off-white crystalline powder
    Density 1.18 g/cm3
    Boiling Point 805.5ºC at 760 mmHg
    Melting Point 217-220ºC
    Flash Point 440.9ºC
    Stability Store in Freezer
    Storage Condition Store only in original container. Keep container tightly closed.
     

    Safety Info

    RTECS KF4997000
    Safety Statements S26; S36
    HS Code 29419000
    Risk Statements R22
    Hazard Codes Xi; Xn
     

    Synthesis Route

    6-O-methylerythromycin A N-oxide→clarithromycin
    Formaldehyde+6-O-methylerythromycin A N-oxide→clarithromycin
    Erythromycin A Oxime+iodomethane→clarithromycin
     

    Toxicity

    Exposure RouteType of TestSpecies ObservedDose/DurationToxic Effects
    Oral TDLo - Lowest published toxic dose Human - woman 30 mg/kg/3D-I 1.Cardiac-pulse rate increase, without fall in BP
    2.Cardiac-change in rate
    Oral LD50 - Lethal dose, 50 percent kill Rodent - rat 1270 mg/kg 1.Behavioral-changes in motor activity (specific assay)
    Intraperitoneal LD50 - Lethal dose, 50 percent kill Rodent - rat 669 mg/kg 1.Sense Organs and Special Senses (Eye)-ptosis
    2.Behavioral-somnolence (general depressed activity)
    3.Lungs, Thorax, or Respiration-respiratory depression
     

    Precursor

    iodomethane
    Erythromycin A Oxime
    Formaldehyde
    clarythromycin 9-O-(2-pyrimidyl)oxime
     

    Downstream Product

    (10E)-10,11-Didehydro-11-deoxy-6-O-methylerythromycin
    Telithromycin intermediate (7A)
    (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-6-[(2S,3R,4S,6R)-3-hydroxy-6-methyl-4-(methylamino)oxan-2-yl]oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione
    3'-N,N-didemethyl-6-O-methylerythromycin A

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