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Home > All categories> Biochemicals and Pharmaceutical Chemicals> Active Pharmaceutical Ingredients (APIs)> Gastrointestinal tract/ metabolism> Cetilistat
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Cetilistat

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Origin: China

Cas No: 282526-98-1

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Quick Details

    CAS No.:
    282526-98-1
    Other Names:
    orlistat
    Place of Origin:
    Shaanxi, China
    Type:
    treatment of obesity
    Grade Standard:
    Food Grade, Medicine Grade
    Usage:
    weight loss powder
    Brand Name:
    Wango
    Model Number:
    P-038
    Purity:
    99%
    Product Name:
    Cetilistat
    Grade:
    A
    Assay:
    HPLC
    MOQ:
    100gram

    Packaging&Delivery

    Packaging Details
    1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
    2) 5kg/carton(1kg net weight, 1.1kg gross weight, packed in five aluminum foil bag)
    3) 25kg/drum (25kg net weight, 28kg gross weight; packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
    Port
    Shanghai port
    Lead Time:
    Quantity(Grams)1 - 1000010001 - 100000>100000
    Est. Time(days)58To be negotiated

  • Property

    CAS No.: 282526-98-1 Formula: C25H39NO3 Molecular Weight: 401.58200

    Description

    Cetilistat is a drug designed to treat obesity. It acts in the same way as the older drug orlistat (Xenical) by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the intestine. Without this enzyme, triglycerides from the diet are prevented from being hydrolyzed into absorbable free fatty acids and are excreted undigested.
    In human trials, cetilistat was shown to produce similar weight loss to orlistat, but also produced similar side effects such as oily, loose stools, fecal incontinence, frequent bowel movements, and flatulence. It is likely that the same precautions would apply in that absorption of fat-soluble vitamins and other fat-soluble nutrients may be inhibited, requiring vitamin supplements to be used to avoid deficiencies.
    Cetilistat has completed Phase 1 and 2 trials in the West and is currently in Phase 3 trials in Japan where it is partnered with Takeda. Norgina BV has now acquired the full global rights to cetilistat from Alizyme after the latter went into administration.
    A published phase 2 trial found cetilistat significantly reduced weight with and was better tolerated than orlistat.

    Basic Info

    Chemical Name Cetilistat
    Synonyms

    2-Hexadecyloxy-6-methyl-4H-3,1-benzoxazin-4-one;
    2-(Hexadecycloxy)-6-methyl-4H-3,1-benzoxazin-4-one;
    Cetilstat;

    CAS No. 282526-98-1
    Molecular Formula C25H39NO3
    Molecular Weight 401.58200
    PSA 52.33000
    LogP 7.35650

    Properties

    Appearance & Physical State Off-white cryst.
    Density 1.027g/cm3
    Boiling Point 509.671ºC at 760 mmHg
    Flash Point 158.925ºC
    Refractive Index 1.521
    Vapor Pressure 0mmHg at 25°C

    Safety Info

    HS Code 2942000000

    Synthesis Route

    Benzoic acid, 2-[[(hexadecyloxy)carbonyl]amino]-5-methyl-+Ethyl chloroformate→Cetilistat
    Benzoic acid, 2-[[(hexadecyloxy)carbonyl]amino]-5-methyl-→Cetilistat

    Precursor

    Benzoic acid, 2-[[(hexadecyloxy)carbonyl]amino]-5-methyl-
    Ethyl chloroformate

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