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Изображение cerivastatin

cerivastatin

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начало: Китай

Кас Но: 145599-86-6

Спецификация: 99%наименьший

минимальный объем заказа: 1 /kg

снабженческая способность: 80 mt/month

опережающий период: OEM 7 дней, пятно 3 дня

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  • Характеристики продукции
  • Описание продукта
  • Property

    CAS No.: 145599-86-6 Formula: C26H32FNO4 Molecular Weight: 441.53500

    Description

    Cerivastatin (brand names: Baycol, Lipobay) is a synthetic member of the class of statins used to lower cholesterol and prevent cardiovascular disease. It was marketed by the pharmaceutical company Bayer A.G. in the late 1990s, competing with Pfizer's highly successful atorvastatin (Lipitor). Cerivastatin was voluntarily withdrawn from the market worldwide in 2001, due to reports of fatal rhabdomyolysis.
    During postmarketing surveillance, 52 deaths were reported in patients using cerivastatin, mainly from rhabdomyolysis and its resultant renal failure. Risks were higher in patients using fibrates, mainly gemfibrozil (Lopid), and in patients using the highest (0.8mg/day) dose of cerivastatin. Bayer A.G. added a contraindication for the concomitant use of cerivastatin and gemfibrozil to the package 18 months after the drug interaction was found. The frequency of deadly cases of rhabdomyolysis with cerivastatin was 16 to 80 times higher than with other statins. Another 385 nonfatal cases of rhabdomyolysis were reported. This put the risk of this (rare) complication at 5-10 times that of the other statins. Cerivastatin also induced myopathy in a dose-dependent manner when administered as monotherapy, but that was revealed only after Bayer was sued and unpublished company documents were opened.

    Basic Info

    Chemical Name cerivastatin
    Synonyms

    Baycol;
    (E,3R,5S)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-di(propan-2-yl)pyridin-3-yl]-3,5-dihydroxyhept-6-enoic acid;
    Lipobay;
    cerivastatin acid;

    CAS No. 145599-86-6
    Molecular Formula C26H32FNO4
    Molecular Weight 441.53500
    PSA 68.65000
    LogP 5.36060

    Properties

    Density 1.181 g/cm3
    Boiling Point 646.3ºC at 760 mmHg
    Flash Point 344.7ºC
    Refractive Index 1.594
    Vapor Pressure 0mmHg at 25°C

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