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Celiprolol Hydrochloride

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Origin: China

Cas No: 57470-78-7

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 57470-78-7 Formula: C20H34ClN3O4 Molecular Weight: 415.95500

    Description

    Cardioselective β1-adrenergic blocker. Antihypertensive, antianginal.

    Basic Info

    Chemical Name Celiprolol Hydrochloride
    Synonyms

    3-[3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea,hydrochloride;

    CAS No. 57470-78-7
    Molecular Formula C20H34ClN3O4
    Molecular Weight 415.95500
    PSA 90.90000
    LogP 4.15660

    Properties

    Appearance & Physical State White Crystalline Solid
    Density 1.114g/cm3
    Boiling Point 586.5ºC at 760 mmHg
    Melting Point 197-200ºC (dec.)
    Flash Point 308.5ºC
    Storage Condition Refrigerator

    Synthesis Route

    3-[3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea→Celiprolol Hydrochloride
    4-nitrophenyl acetate→Celiprolol Hydrochloride
    4-nitrophenol→Celiprolol Hydrochloride

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Oral TDLo - Lowest published toxic dose Human - man 40 mg/kg/2W-I 1.Gastrointestinal-hypermotility, diarrhea
    2.Nutritional and Gross Metabolic-weight loss or decreased weight gain
    Oral LD50 - Lethal dose, 50 percent kill Rodent - rat 2157 mg/kg 1.Sense Organs and Special Senses (Eye)-mydriasis (pupillary dilation)
    2.Behavioral-convulsions or effect on seizure threshold
    3.Lungs, Thorax, or Respiration-dyspnea
    Subcutaneous LD50 - Lethal dose, 50 percent kill Rodent - rat 754 mg/kg 1.Sense Organs and Special Senses (Eye)-mydriasis (pupillary dilation)
    2.Behavioral-convulsions or effect on seizure threshold
    3.Lungs, Thorax, or Respiration-dyspnea

    Precursor

    3-[3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea
    4-nitrophenol
    1-[5-nitro-2-(oxiran-2-ylmethoxy)phenyl]ethanone
    2'-Hydroxy-5'-nitroacetophenone

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