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cefotetan

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Origin: China

Cas No: 69712-56-7

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

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  • Products Specification
  • Product Description

  • Quick Details

    CAS No.:
    69712-56-7
    Other Names:
    Cefotetan disodium
    MF:
    C17H17N7O8S4
    EINECS No.:
    277-834-9
    Place of Origin:
    China
    Type:
    Anesthetic Agents
    Grade Standard:
    Medicine Grade
    Brand Name:
    TOP
    Model Number:
    A
    Purity:
    99%
    grade:
    pharma grade

    Packaging&Delivery

    Packaging Details
    1kg/Aluminum foil packet; 25kg cardboard drum; 1G 50G 25kg/drum or customized requirement
    Port
    China main port

  • Property

    CAS No.: 69712-56-7 Formula: C17H17N7O8S4 Molecular Weight: 575.61900

    Description

    An antibiotic related to Cephalosporin, used in the treatment of bacterial infections.

    Basic Info

    Chemical Name cefotetan
    Synonyms

    Apatef;
    Apacef;
    Yamatetan;
    CEFOTETAN;
    Cefotetan acid;
    Ceftenon;
    Cepan Darvilen;
    Cefotetan disodium;
    CEFOTETAN SODIUM;

    CAS No. 69712-56-7
    Molecular Formula C17H17N7O8S4
    Molecular Weight 575.61900
    PSA 321.13000
    LogP -0.36840

    Properties

    Appearance & Physical State Off-white solid
    Density 2.07 g/cm3
    Melting Point 173-178ºC (dec.)
    Refractive Index 1.921
    Storage Condition Store at 0-5ºC

    Synthesis Route

    cefotetan disodium salt→cefotetan
    7β-bromoacetamido-7α-methoxy-3-(1-methyltetrazol-5-yl)thiomethyl-Δ3-cephem-4-carboxylic acid+3-oxo-5-sulfanyl-1,2-thiazole-4-carboxylic acid,sodium→cefotetan
    (6R,7S)-7-[[2-[(4-carboxy-3-oxo-1,2-thiazol-5-yl)sulfanyl]acetyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid→cefotetan

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Oral LD50 - Lethal dose, 50 percent kill Rodent - rat >10 gm/kg 1.Gastrointestinal-hypermotility, diarrhea
    Intraperitoneal LD50 - Lethal dose, 50 percent kill Rodent - rat 8250 mg/kg 1.Sense Organs and Special Senses (Eye)-ptosis
    2.Behavioral-convulsions or effect on seizure threshold
    3.Blood-changes in spleen
    Subcutaneous LD50 - Lethal dose, 50 percent kill Rodent - rat >10 gm/kg 1.Behavioral-tremor
    2.Skin and Appendages-hair
    3.Nutritional and Gross Metabolic-body temperature decrease

    Precursor

    cefotetan disodium salt
    3-oxo-5-sulfanyl-1,2-thiazole-4-carboxylic acid,sodium
    7β-bromoacetamido-7α-methoxy-3-(1-methyltetrazol-5-yl)thiomethyl-Δ3-cephem-4-carboxylic acid
    (6R,7S)-7-[[2-[(4-carboxy-3-oxo-1,2-thiazol-5-yl)sulfanyl]acetyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

    Downstream Product

    (6R,7S)-7-[[2-[(4-carboxy-3-oxo-1,2-thiazol-5-yl)sulfanyl]acetyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

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