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Cefditoren Acid Sodium Salt

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Origin: China

Cas No: 104146-53-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 104146-53-4 Formula: C19H17N6NaO5S3 Molecular Weight: 528.56000

Description

Third generation cephalosporin; active metabolite of orally absorbed pivaloyloxymethyl ester prodrug. An antibacterial.

Basic Info

Chemical Name	Cefditoren Acid Sodium Salt
Synonyms	ME-1206; (6R,7R)-7-[(Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetylamino]-3-[(Z)-2-(4-methyl-5-thiazolyl)vinyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]octa-2-ene-2-carboxylic acid sodium salt; Cefditoren acid,sodium salt; sodium (6R,7R)-7-[2-amino-4-thiazolyl[(methoxyimino)acetyl]amino]-3-[(Z)-2-(4-methyl-5-thiazolyl)vinyl]-3-cephem-4-carboxylate; [6R-[3(Z),6a,7b(Z)]]-7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[2-(4-methyl-5-thiazolyl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-carboxylic acid sodium salt; (6R-(3(Z),6alpha,7beta(Z)))-7-(((2-Amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(2-(4-methyl-5-thiazolyl)ethenyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monosodium salt; Cefditoren sodium; sodium (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-acetyl]amino]-3-[(E)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7-<(Z)-2-(2-Aminothiazol-4-yl)-2-methoxyiminoacetamido>-3(Z)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylic acid sodium salt;
CAS No.	104146-53-4
Molecular Formula	C19H17N6NaO5S3
Molecular Weight	528.56000
PSA	244.71000
LogP	0.86800

Synthesis Route

cefditoren acid+cefditoren→Cefditoren Acid Sodium Salt+7-[(Z)-2-(2-Aminothiazol-4-yl)-2-methoxyiminoacetamido]-3(E)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylic acid sodium salt
p-Methoxybenzyl 7-((Z)-2-(2-tritylaminothiazol-4-yl)-2-methoxyiminoacetamido)-3(Z)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylate→Cefditoren Acid Sodium Salt
4-Methylthiazole-5-carboxaldehyde→Cefditoren Acid Sodium Salt

Precursor

4-Methoxybenzyl 3-chloromethyl-7-(2-phenylacetamido)-3-cephem-4-carboxylate
p-Methoxybenzyl 7-((Z)-2-(2-tritylaminothiazol-4-yl)-2-methoxyiminoacetamido)-3(Z)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylate
cefditoren
cefditoren acid

Downstream Product

cefditoren pivoxil

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