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Изображение cefazolin

cefazolin

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начало: Китай

Кас Но: 25953-19-9

Спецификация: 99%наименьший

минимальный объем заказа: 1 /kg

снабженческая способность: 50 mt/month

опережающий период: OEM 7 дней, пятно 3 дня

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  • Характеристики продукции
  • Описание продукта
  • Quick Details

    CAS No.:
    25953-19-9
    Other Names:
    Cefamedin
    MF:
    C14H14N8O4S3
    EINECS No.:
    247-362-8
    Place of Origin:
    Shaanxi, China
    Type:
    Antibiotic and Antimicrobial Agents
    Grade Standard:
    Medicine Grade
    Usage:
    Animal Pharmaceuticals
    Brand Name:
    HS
    Model Number:
    HS-Cefazolin
    Purity:
    99% Min
    Product Name:
    Cefazolin
    Density:
    2.01g/cm3
    MW:
    454.51
    Solubility:
    aqueous acetone, and aqueous ethanol. Insoluble in water
    pK Values:
    -2.6 (Predicted), pKb- 0.45 (Predicted)
    COA:
    Available
    Sample:
    Available
    Storage:
    Cool Dry Place
    Shelf life:
    2 Years
    IC50:
    -IC50 - 0.88 mM (human)

    Packaging&Delivery

    Packaging Details
    Cefazolin
    1KG/Aluminium foil bag, 5 bags in a carton . For large quantity: 25KG/Fiber Drum in net weight; 28KG/Fiber Drum in gross weight (Can be customized)
    Port
    Chinese main port
    Lead Time:
    Quantity(Kilograms)1 - 1>1
    Est. Time(days)5To be negotiated
  • Property

    CAS No.: 25953-19-9 Formula: C14H14N8O4S3 Molecular Weight: 454.50700

    Description

    Cefazolin is an antibacterial compound derived from 7-amino-cephalosporanic acid.

    Basic Info

    Chemical Name cefazolin
    Synonyms

    Cephazolin;
    Cefazolina;
    Cefazolin;
    Cefazoline;
    Cephazolidin;
    Cefazolinum;
    Ancef;
    (6R)-3-(5-methyl-[1,3,4]thiadiazol-2-ylsulfanylmethyl)-8-oxo-7t-(2-tetrazol-1-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid;
    Cefamezin;
    (6R,7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;
    Cephamezine;
    Cephazoline;

    CAS No. 25953-19-9
    Molecular Formula C14H14N8O4S3
    Molecular Weight 454.50700
    PSA 234.93000
    LogP -0.30730

    Properties

    Appearance & Physical State Needles from aq acetone.
    Density 2.01g/cm3
    Melting Point 198-200ºC
    Refractive Index 1.961
    Storage Condition Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

    Safety Info

    Safety Statements S26; S36
    HS Code 3004909090
    Risk Statements R20/21/22
    Hazard Codes Xn

    Synthesis Route

    cefazolin sodiumcefazolin
    2-(1H-tetrazol-1-yl)acetic pivalic anhydride+(6R,7S)-7-amino-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,hydrochloridecefazolin
    7-((tetrazol-1'-yl)acetylamino)-3-acetyloxymethyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid+5-methyl-3H-1,3,4-thiadiazole-2-thionecefazolin

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Intravenous LD50 - Lethal dose, 50 percent kill Rodent - mouse 3 gm/kg 1.Details of toxic effects not reported other than lethal dose value
    Intramuscular LD50 - Lethal dose, 50 percent kill Rodent - mouse 4 gm/kg 1.Details of toxic effects not reported other than lethal dose value
    Intraperitoneal TDLo - Lowest published toxic dose Rodent - rat 164 gm/kg/26W-I 1.Blood-normocytic anemia
    2.Blood-changes in serum composition (e.g. TP, bilirubin, cholesterol)
    3.Biochemical-Enzyme inhibition, induction, or change in blood or tissue levels-transaminases

    Precursor

    7-((tetrazol-1'-yl)acetylamino)-3-acetyloxymethyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
    (6R,7S)-7-amino-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,hydrochloride
    5-methyl-3H-1,3,4-thiadiazole-2-thione
    2-(1H-tetrazol-1-yl)acetic pivalic anhydride

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