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cefazolin

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Origin: China

Cas No: 25953-19-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
25953-19-9
Other Names:
Cefamedin
MF:
C14H14N8O4S3
EINECS No.:
247-362-8
Place of Origin:
Shaanxi, China
Type:
Antibiotic and Antimicrobial Agents
Grade Standard:
Medicine Grade
Usage:
Animal Pharmaceuticals
Brand Name:
HS
Model Number:
HS-Cefazolin
Purity:
99% Min
Product Name:
Cefazolin
Density:
2.01g/cm3
MW:
454.51
Solubility:
aqueous acetone, and aqueous ethanol. Insoluble in water
pK Values:
-2.6 (Predicted), pKb- 0.45 (Predicted)
COA:
Available
Sample:
Available
Storage:
Cool Dry Place
Shelf life:
2 Years
IC50:
-IC50 - 0.88 mM (human)
Packaging&Delivery
Packaging Details
Cefazolin
1KG/Aluminium foil bag, 5 bags in a carton . For large quantity: 25KG/Fiber Drum in net weight; 28KG/Fiber Drum in gross weight (Can be customized)
Port
Chinese main port
Lead Time:
Quantity(Kilograms) 1 - 1 >1
Est. Time(days) 5 To be negotiated

Property

CAS No.: 25953-19-9 Formula: C14H14N8O4S3 Molecular Weight: 454.50700

Description

Cefazolin is an antibacterial compound derived from 7-amino-cephalosporanic acid.

Basic Info

Chemical Name	cefazolin
Synonyms	Cephazolin; Cefazolina; Cefazolin; Cefazoline; Cephazolidin; Cefazolinum; Ancef; (6R)-3-(5-methyl-[1,3,4]thiadiazol-2-ylsulfanylmethyl)-8-oxo-7t-(2-tetrazol-1-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Cefamezin; (6R,7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Cephamezine; Cephazoline;
CAS No.	25953-19-9
Molecular Formula	C14H14N8O4S3
Molecular Weight	454.50700
PSA	234.93000
LogP	-0.30730

Properties

Appearance & Physical State	Needles from aq acetone.
Density	2.01g/cm3
Melting Point	198-200ºC
Refractive Index	1.961
Storage Condition	Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Safety Info

Safety Statements	S26; S36
HS Code	3004909090
Risk Statements	R20/21/22
Hazard Codes	Xn

Synthesis Route

cefazolin sodium→cefazolin
2-(1H-tetrazol-1-yl)acetic pivalic anhydride+(6R,7S)-7-amino-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,hydrochloride→cefazolin
7-((tetrazol-1'-yl)acetylamino)-3-acetyloxymethyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid+5-methyl-3H-1,3,4-thiadiazole-2-thione→cefazolin

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Intravenous	LD50 - Lethal dose, 50 percent kill	Rodent - mouse	3 gm/kg	1.Details of toxic effects not reported other than lethal dose value
Intramuscular	LD50 - Lethal dose, 50 percent kill	Rodent - mouse	4 gm/kg	1.Details of toxic effects not reported other than lethal dose value
Intraperitoneal	TDLo - Lowest published toxic dose	Rodent - rat	164 gm/kg/26W-I	1.Blood-normocytic anemia 2.Blood-changes in serum composition (e.g. TP, bilirubin, cholesterol) 3.Biochemical-Enzyme inhibition, induction, or change in blood or tissue levels-transaminases

Precursor

7-((tetrazol-1'-yl)acetylamino)-3-acetyloxymethyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
(6R,7S)-7-amino-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,hydrochloride
5-methyl-3H-1,3,4-thiadiazole-2-thione
2-(1H-tetrazol-1-yl)acetic pivalic anhydride

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