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Cbz-L-tert-Leucine

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Origin: China

Cas No: 62965-10-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 62965-10-0 Formula: C14H19NO4 Molecular Weight: 265.30500

Description

Leucine derivative used in the preparation of various pharmaceutical agents such as TRPV4 antagonists, HIV-1 protease inhibitors and serine protease inhibitors.

Basic Info

Chemical Name	Cbz-L-tert-Leucine
Synonyms	3-Methyl-N-[(phenylmethoxy)carbonyl]-L-valine; Z-TLE-OH; (2S)-3,3-Dimethyl-2-[(phenylmethoxy)carbonyl]aminobutyric acid; N-Carbobenzoxy-(S)-tert-leucine; Z-(TBU)GLY-OH; Z-L-TERT-LEUCINE; N-benzyloxycarbonyl-3-methyl-L-valine; CBZL-L-TERT-LEUCINE; N-Benzyloxycarbonyl-tert-leucine; Z-L-T-BUTYLGLYCINE; (S)-2-(((benzyloxy)carbonyl)amino)-3,3-dimethylbutanoic acid; Cbz-N-tert-butylglycine; Benzyloxycarbonyl-L-tert-leucine; 2(S)-<<(benzyloxy)carbonyl>amino>-3,3-dimethylbutanoic acid; (S)-2-(Benzyloxycarbonylamino)-3,3-dimethylbutanoic acid; N-Benzyloxycarbonyl-L-tert-leucine;
CAS No.	62965-10-0
Molecular Formula	C14H19NO4
Molecular Weight	265.30500
PSA	75.63000
LogP	2.80300

Properties

Appearance & Physical State	White powder
Density	1.16 g/cm3
Boiling Point	436.4ºC at 760 mmHg
Flash Point	217.7ºC
Refractive Index	1.528
Storage Condition	Refrigerator

Safety Info

HS Code	2924299090

Synthesis Route

N-(Benzyloxycarbonyloxy)succinimide+L-tert-Leucine→Cbz-L-tert-Leucine
N-cyclohexylcyclohexanamine,(2S)-3,3-dimethyl-2-(phenylmethoxycarbonylamino)butanoic acid→Cbz-L-tert-Leucine
L-tert-Leucine+Benzyl chloroformate→Cbz-L-tert-Leucine

Precursor

Benzyl chloroformate
N-(Benzyloxycarbonyloxy)succinimide
L-tert-leucinamide
L-tert-Leucine

Downstream Product

Methyl (2S)-2-amino-3,3-dimethylbutanoate
L-tert-Leucine

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