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calcitriol

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Origin: China

Cas No: 32222-06-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
32222-06-3
Other Names:
1alpha,25-Dihydroxycholecalciferol
MF:
C27H44O3
EINECS No.:
32222-06-3
Place of Origin:
Shandong, China
Type:
Antineoplastic Agents
Grade Standard:
Medicine Grade
Usage:
Animal Pharmaceuticals
Brand Name:
Ocean
Model Number:
TOP
Purity:
99%min
Product Name:
Calcitriol
Molecular Weight:
416.64
Melting point:
119-1210C
Boiling point:
474.91°C (rough estimate)
Density:
1.0362 (rough estimate)
Flash point:
14 °C
Storage:
2-8°C
Merck:
14,1644
Grade:
Phamaceutical Grade
Shelf life:
3 Years
Packaging&Delivery
Packaging Details
25kg/drum,1kg/bag or according to customer request
Lead Time:
Quantity(Grams) 1 - 1 >1
Est. Time(days) 15 To be negotiated

Property

CAS No.: 32222-06-3 Formula: C27H44O3 Molecular Weight: 416.63600

Description

Calcitriol (INN), also called 1,25-dihydroxycholecalciferol or 1,25-dihydroxyvitamin D3, is the hormonally active metabolite of vitamin D with three hydroxyl groups (abbreviated 1,25-(OH)2D3 or simply 1,25(OH)2D), It was first identified by Michael F. Holick in work published in 1971. Calcitriol increases the level of calcium (Ca2+) in the blood by increasing the uptake of calcium from the gut into the blood, and possibly increasing the release of calcium into the blood from bone.

Basic Info

Chemical Name	calcitriol
Synonyms	(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol; 1α,25-Dihydroxyvitamin D3; 1,25-Dihydroxycholecalciferol;
CAS No.	32222-06-3
Molecular Formula	C27H44O3
Molecular Weight	416.63600
PSA	60.69000
LogP	5.70470

Properties

Appearance & Physical State	White Crystalline Powder
Density	1.06g/cm3
Boiling Point	565ºC at 760 mmHg
Melting Point	119-121ºC
Flash Point	238.4ºC
Refractive Index	1.547
Storage Condition	2-8ºC

Safety Info

RTECS	FZ4645000
Hazard Class	6.1(a)
Safety Statements	S36/37/39-S45
HS Code	2942000000
Packing Group	I
WGK Germany	3
RIDADR	UN 2811
Risk Statements	R26/27/28; R63
Hazard Codes	T+
Hazard Declaration	H300
Signal Word	Danger
Symbol	GHS06

Synthesis Route

(1S),3(R)-bis<(tert-butyldimethylsilyl)oxy>-9,10-secocholesta-5(Z),7(E),10(19)-trien-25-ol→calcitriol
(((1R,3S,Z)-5-(2-((1R,3aS,7aR,E)-1-((R)-6-(methoxymethoxy)-6-methylheptan-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diyl)bis(oxy))bis(triisopropylsilane)→calcitriol
→calcitriol

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - rat	620 ug/kg	1.Details of toxic effects not reported other than lethal dose value
Intraperitoneal	LD50 - Lethal dose, 50 percent kill	Rodent - rat	>5 mg/kg	1.Behavioral-somnolence (general depressed activity) 2.Gastrointestinal-hypermotility, diarrhea 3.Kidney, Ureter, Bladder-other changes
Subcutaneous	LD50 - Lethal dose, 50 percent kill	Rodent - rat	66 ug/kg	1.Behavioral-somnolence (general depressed activity) 2.Behavioral-ataxia 3.Nutritional and Gross Metabolic-body temperature decrease

Precursor

7,8-cis-1α,25-dihydroxyvitamin D3

(1S),3(R)-bis<(tert-butyldimethylsilyl)oxy>-9,10-secocholesta-5(Z),7(E),10(19)-trien-25-ol
(((1R,3S,Z)-5-(2-((1R,3aS,7aR,E)-1-((R)-6-(methoxymethoxy)-6-methylheptan-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diyl)bis(oxy))bis(triisopropylsilane)

Downstream Product

5,6-trans-1alpha,25-Dihydroxyvitamin D3

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