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calcitriol

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Origin: China

Cas No: 32222-06-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

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  • Products Specification
  • Product Description
  • Quick Details

    CAS No.:
    32222-06-3
    Other Names:
    1alpha,25-Dihydroxycholecalciferol
    MF:
    C27H44O3
    EINECS No.:
    32222-06-3
    Place of Origin:
    Shandong, China
    Type:
    Antineoplastic Agents
    Grade Standard:
    Medicine Grade
    Usage:
    Animal Pharmaceuticals
    Brand Name:
    Ocean
    Model Number:
    TOP
    Purity:
    99%min
    Product Name:
    Calcitriol
    Molecular Weight:
    416.64
    Melting point:
    119-1210C
    Boiling point:
    474.91°C (rough estimate)
    Density:
    1.0362 (rough estimate)
    Flash point:
    14 °C
    Storage:
    2-8°C
    Merck:
    14,1644
    Grade:
    Phamaceutical Grade
    Shelf life:
    3 Years

    Packaging&Delivery

    Packaging Details
    25kg/drum,1kg/bag or according to customer request
    Lead Time:
    Quantity(Grams)1 - 1>1
    Est. Time(days)15To be negotiated
  • Property

    CAS No.: 32222-06-3 Formula: C27H44O3 Molecular Weight: 416.63600

    Description

    Calcitriol (INN), also called 1,25-dihydroxycholecalciferol or 1,25-dihydroxyvitamin D3, is the hormonally active metabolite of vitamin D with three hydroxyl groups (abbreviated 1,25-(OH)2D3 or simply 1,25(OH)2D), It was first identified by Michael F. Holick in work published in 1971. Calcitriol increases the level of calcium (Ca2+) in the blood by increasing the uptake of calcium from the gut into the blood, and possibly increasing the release of calcium into the blood from bone.

    Basic Info

    Chemical Name calcitriol
    Synonyms

    (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol;
    1α,25-Dihydroxyvitamin D3;
    1,25-Dihydroxycholecalciferol;

    CAS No. 32222-06-3
    Molecular Formula C27H44O3
    Molecular Weight 416.63600
    PSA 60.69000
    LogP 5.70470

    Properties

    Appearance & Physical State White Crystalline Powder
    Density 1.06g/cm3
    Boiling Point 565ºC at 760 mmHg
    Melting Point 119-121ºC
    Flash Point 238.4ºC
    Refractive Index 1.547
    Storage Condition 2-8ºC

    Safety Info

    RTECS FZ4645000
    Hazard Class 6.1(a)
    Safety Statements S36/37/39-S45
    HS Code 2942000000
    Packing Group I
    WGK Germany 3
    RIDADR UN 2811
    Risk Statements R26/27/28; R63
    Hazard Codes T+
    Hazard Declaration H300
    Signal Word Danger
    Symbol GHS06

    Synthesis Route

    (1S),3(R)-bis<(tert-butyldimethylsilyl)oxy>-9,10-secocholesta-5(Z),7(E),10(19)-trien-25-olcalcitriol
    (((1R,3S,Z)-5-(2-((1R,3aS,7aR,E)-1-((R)-6-(methoxymethoxy)-6-methylheptan-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diyl)bis(oxy))bis(triisopropylsilane)calcitriol
    calcitriol

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Oral LD50 - Lethal dose, 50 percent kill Rodent - rat 620 ug/kg 1.Details of toxic effects not reported other than lethal dose value
    Intraperitoneal LD50 - Lethal dose, 50 percent kill Rodent - rat >5 mg/kg 1.Behavioral-somnolence (general depressed activity)
    2.Gastrointestinal-hypermotility, diarrhea
    3.Kidney, Ureter, Bladder-other changes
    Subcutaneous LD50 - Lethal dose, 50 percent kill Rodent - rat 66 ug/kg 1.Behavioral-somnolence (general depressed activity)
    2.Behavioral-ataxia
    3.Nutritional and Gross Metabolic-body temperature decrease

    Precursor

    7,8-cis-1α,25-dihydroxyvitamin D3

    (1S),3(R)-bis<(tert-butyldimethylsilyl)oxy>-9,10-secocholesta-5(Z),7(E),10(19)-trien-25-ol
    (((1R,3S,Z)-5-(2-((1R,3aS,7aR,E)-1-((R)-6-(methoxymethoxy)-6-methylheptan-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diyl)bis(oxy))bis(triisopropylsilane)

    Downstream Product

    5,6-trans-1alpha,25-Dihydroxyvitamin D3

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