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bendroflumethiazide

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Origin: China

Cas No: 73-48-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 73-48-3 Formula: C15H14F3N3O4S2 Molecular Weight: 421.41500

Description

Bendroflumethiazide (INN), formerly bendrofluazide (BAN), trade name Aprinox, is a thiazide diuretic used to treat hypertension.
Bendroflumethiazide is a thiazide diuretic which works by inhibiting sodium reabsorption at the beginning of the distal convoluted tubule (DCT). Water is lost as a result of more sodium reaching the collecting ducts. Bendroflumethiazide has a role in the treatment of mild heart failure although loop diuretics are better for reducing overload. The main use of bendroflumethiazide currently is in hypertension (part of the effect is due to vasodilation).

Basic Info

Chemical Name	bendroflumethiazide
Synonyms	Pluryl; Aprinox; Bendroflumethiazide; Centyl; bendroflumethazide; Neo-naclex; benzoflumethiazide; Bendrofluazide; Salures; 3-benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1λ<sup>6</sup>,2,4-benzothiadiazine-7-sulfonamide; Berkozide; Naturetin; bendroflumetazide; Benzylrodiuran;
CAS No.	73-48-3
Molecular Formula	C15H14F3N3O4S2
Molecular Weight	421.41500
PSA	135.12000
LogP	4.95410

Properties

Appearance & Physical State	white solid
Density	1.528g/cm3
Boiling Point	602.1ºC at 760 mmHg
Melting Point	205-207ºC
Flash Point	317.9ºC
Refractive Index	1.583
Storage Condition	Refrigerator

Synthesis Route

4-Amino-6-(trifluoromethyl)benzene-1,3-disulfonamide+phenylacetaldehyde→bendroflumethiazide
4-Amino-6-(trifluoromethyl)benzene-1,3-disulfonamide+Phenylacetaldehyde dimethyl acetal→bendroflumethiazide

Precursor

Phenylacetaldehyde dimethyl acetal
4-Amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
phenylacetaldehyde

Downstream Product

(R)-Bendroflumethiazide
(3S)-3-benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1λ<sup>6</sup>,2,4-benzothiadiazine-7-sulfonamide
4-Amino-6-(trifluoromethyl)benzene-1,3-disulfonamide

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