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azithromycin

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начало: Китай

Кас Но: 83905-01-5

Спецификация: 99%наименьший

минимальный объем заказа: 1 /kg

снабженческая способность: 50 mt/month

опережающий период: OEM 7 дней, пятно 3 дня

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Характеристики продукции
Описание продукта

Property

CAS No.: 83905-01-5 Formula: C38H72N2O12 Molecular Weight: 748.98400

Description

Azithromycin is an antibiotic useful for the treatment of a number of bacterial infections. This includes middle ear infections, strep throat, pneumonia, traveler's diarrhea, and certain other intestinal infections. It may also be used for a number of sexually transmitted infections including chlamydia and gonorrhea infections. Along with other medications, it may also be used for malaria. It can be taken by mouth or intravenously with doses once per day.
Common side effects include nausea, vomiting, diarrhea and upset stomach. An allergic reaction or a type of diarrhea caused by Clostridium difficile is possible. No harm has been found with use during pregnancy. Its safety during breastfeeding is not confirmed, but it is likely safe. Azithromycin is an azalide, a type of macrolide antibiotic. It works by decreasing the production of protein, thus stopping bacterial growth.
Azithromycin was first made in 1980. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. It is available as a generic medication and is sold under many trade names worldwide. The wholesale cost in the developing world is about 0.18 to 2.98 USD per dose. In the United States it is about 33 USD for a course of treatment.

Basic Info

Chemical Name	azithromycin
Synonyms	Aziwok; Azimin; xz405; Azenil; Aztrin; XZ-450; Azithromycin; Setron; Zifin; Tobil; Zeto;
CAS No.	83905-01-5
Molecular Formula	C38H72N2O12
Molecular Weight	748.98400
PSA	180.08000
LogP	1.83860

Properties

Appearance & Physical State	white crystalline powder
Density	1.18 g/cm3
Boiling Point	822.1ºC at 760 mmHg
Melting Point	113-115ºC
Flash Point	451ºC
Refractive Index	1.536
Stability	Stable. Incompatible with strong oxidizing agents.
Storage Condition	Store at -20ºC

Safety Info

RTECS	RN6960000
HS Code	2941500000
Hazard Codes	Xi

Synthesis Route

Formaldehyde+(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one→azithromycin
→azithromycin
Formaldehyde→azithromycin

Precursor

formic acid
Formaldehyde
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one

Downstream Product

(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-Ethyl-3,4,10,13-tetrahydro xy-3,5,6,8,10,12,14-heptamethyl-15-oxo-1-oxa-6-azacyclopentadecan -11-yl 3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranoside
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-11-[(2S,3R,4S,6R)-3-hydroxy-6-methyl-4-(methylamino)oxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one
3'-N,N-Di(desmethyl) Azithromycin
L-cladinose

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