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amoxicillin

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Origin: China

Cas No: 26787-78-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Product Name:	Amoxicillin
Synonyms:	4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-; 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-; 6-{[Amino(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
CAS RN.:	26787-78-0
EINECS:	248-003-8
Molecular Weight:	419.46
Molecular Formula:	C16H19N3O5S·3H2O
Boiling Point(℃):	743.2°C at 760 mmHg
Flash Point(℃):	403.3°C

Property

CAS No.: 26787-78-0 Formula: C16H19N3O5S Molecular Weight: 365.40400

Description

Amoxicillin (amox), also spelled amoxycillin, is an antibiotic useful for the treatment of a number of bacterial infections. It is the first line treatment for middle ear infections. It may also be used for strep throat, pneumonia, skin infections, and urinary tract infections among others. It is taken by mouth.
Common side effects include nausea and rash. It may also increase the risk of yeast infections and, when used in combination with clavulanic acid, diarrhea. It should not be used in those who are allergic to penicillin. While usable in those with kidney problems, the dose may need to be decreased. Its use in pregnancy and breastfeeding does not appear to be harmful.
Amoxicillin first became available in 1972. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. It is one of the most commonly prescribed antibiotics in children. Amoxicillin is available as a generic medication. It has a wholesale costs in the developing world of between 0.02 and 0.05 USD per pill. In the United States ten days of treatment costs about 16 USD.

Basic Info

Chemical Name	amoxicillin
Synonyms	Optium; Amoxicillin; Utimox; amolin; Amopen; amoxi; sumox; p-Hydroxyampicillin; amoxil; clavulanate; amoxycillin; Trimox; blp1410;
CAS No.	26787-78-0
Molecular Formula	C16H19N3O5S
Molecular Weight	365.40400
PSA	158.26000
LogP	1.05280

Properties

Appearance & Physical State	solid
Density	1.54g/cm3
Boiling Point	743.2ºC at 760 mmHg
Flash Point	403.3ºC
Stability	Stable. Incompatible with strong oxidizing agents.
Storage Condition	2-8ºC
Vapor Pressure	3.39E-23mmHg at 25°C

Safety Info

Safety Statements	S22-S36/37
HS Code	2941109200
Risk Statements	R42/43
Hazard Codes	Xn

Synthesis Route

6-aminopenicillanic acid→amoxicillin+2-Ethylhexanoyl chloride
6-aminopenicillanic acid+Methyl 2-((4-hydroxyphenyl)amino)acetate hydrochloride→N-(p-hydroxyphenyl)glycine+amoxicillin
D(-)-p-hydroxy-N-(1-ethoxycarbonyl-2-propenyl)-alpha-aminophenylacetic acid potassium salt+N-triisopropylsilyl-2-oxazolidinone→amoxicillin

Precursor

(2S)-2-amino-2-(4-hydroxyphenyl)acetic acid
D(-)-p-hydroxy-N-(1-ethoxycarbonyl-2-propenyl)-alpha-aminophenylacetic acid potassium salt
Ethylene chlorophosphite
N-triisopropylsilyl-2-oxazolidinone

Downstream Product

amoxicillin sodium
piperazine-2,5-dione
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole

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