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amlodipine benzenesulfonate

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Origem: China

Cas No: 111470-99-6

Especificação: 99%Min

Quantidade de ordem min: 1 /kg

Capacidade de fornecimento: 100 mt/month

Tempo de espera: 7 dias para OEM, 3 dias para produtos prontos

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Especificação de produtos
Descrição do produto

Property

CAS No.: 111470-99-6 Formula: C26H31ClN2O8S Molecular Weight: 567.05100

Description

A dihydropyridine calcium channel blocker. Used as an antianginal and antihypertensive.

Basic Info

Chemical Name	amlodipine benzenesulfonate
Synonyms	Amlodipine Besilate; Amlodipine besylate; benzenesulfonic acid,3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate;
CAS No.	111470-99-6
Molecular Formula	C26H31ClN2O8S
Molecular Weight	567.05100
PSA	162.63000
LogP	5.30950

Properties

Appearance & Physical State	White powder
Density	1.227g/cm3
Boiling Point	527.2ºC at 760 mmHg
Melting Point	199-201ºC
Flash Point	272.6ºC
Vapor Pressure	3.34E-11mmHg at 25°C

Safety Info

RTECS	US7967700
Safety Statements	S26; S36
HS Code	2933990090
WGK Germany	3
Risk Statements	R22
Hazard Codes	Xn

Synthesis Route

amlodipine+benzenesulfonic acid→amlodipine benzenesulfonate
amlodipine formate+Benzenesulfonic Acid Sodium Salt→amlodipine benzenesulfonate
amlodipine acetate+Benzenesulfonic Acid Sodium Salt→amlodipine benzenesulfonate

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Unreported	TDLo - Lowest published toxic dose	Human - woman	6 mg/kg/60D-I	1.Sense Organs and Special Senses (Olfaction)-effect, not otherwise specified
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - rat	393 mg/kg	1.Sense Organs and Special Senses (Eye)-ptosis 2.Lungs, Thorax, or Respiration-respiratory depression 3.Blood-other changes
Intraperitoneal	LD50 - Lethal dose, 50 percent kill	Rodent - rat	42 mg/kg	1.Details of toxic effects not reported other than lethal dose value