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amarogentin

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Origin: China

Cas No: 21018-84-8

Specification: 99%min

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  • Products Specification
  • Product Description
  • Property

    CAS No.: 21018-84-8 Formula: C29H30O13 Molecular Weight: 586.54100

    Description

    Amarogentin is a chemical compound found in gentian (Gentiana lutea) or in Swertia chirata.
    Amarogentin and gentiopicrin, the bitter glycosides from gentian root; Gentian root has a long history of use as a herbal bitter in the treatment of digestive disorders and is an ingredient of many proprietary medicines. The bitter principles of gentian root are secoiridoid glycosides amarogentin and gentiopicrin. The former is one of the most bitter natural compounds known and is used as a scientific basis for measuring bitterness. In humans, it activates the bitter taste receptor hTAS2R50. The biphenylcarboxylic acid moiety is biosynthesized by a polyketide-type pathway, with three units of acetyl-CoA and one unit of 3-hydroxybenzoyl-CoA, this being formed from an early shikimate pathway intermediate and not via cinnamic or benzoic acid.
    It also shows an antileishmanial activity in animal models being an inhibitor of topoisomerase I.

    Basic Info

    Chemical Name amarogentin
    Synonyms

    amorogentin;
    AMAROGENTIN;
    sweroside-2'-O-3",5",3'''-trihydroxy-biphenyl-2''-carboxylic acid;
    amarosgentin;
    Amarogentin Hydrate;

    CAS No. 21018-84-8
    Molecular Formula C29H30O13
    Molecular Weight 586.54100
    PSA 201.67000
    LogP 1.05690

    Properties

    Density 1.59 g/cm3
    Boiling Point 928.5ºC at 760 mmHg
    Melting Point 229-230ºC
    Flash Point 306.9ºC
    Refractive Index 1.692
    Vapor Pressure 0mmHg at 25°C

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