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Aleglitazar

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Origin: China

Cas No: 475479-34-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 475479-34-6 Formula: C24H23NO5S Molecular Weight: 437.50800

Description

Aleglitazar is a peroxisome proliferator-activated receptor agonist (hence a PPAR modulator ) with affinity to PPARα and PPARγ, which was under development by Hoffmann–La Roche for the treatment of type II diabetes. It is no longer in phase III clinical trials.

Basic Info

Chemical Name	Aleglitazar
Synonyms	UNII-41T4OAG59U; R-1439; (2S)-2-methoxy-3-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl]propanoic acid;
CAS No.	475479-34-6
Molecular Formula	C24H23NO5S
Molecular Weight	437.50800
PSA	110.03000
LogP	5.12830

Properties

Density	1.29
Boiling Point	665.151ºC at 760 mmHg
Flash Point	356.071ºC
Refractive Index	1.627

Synthesis Route

(Z)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-acrylic acid→Aleglitazar+(2R)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propionic acid
(Z)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-acrylic acid→Aleglitazar
→Aleglitazar

Precursor

(S)-4-benzyl-3-((S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propionyl)-oxazolidin-2-one
(Z)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-acrylic acid

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