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albuterol

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Origin: China

Cas No: 18559-94-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

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  • Product Description
  • Property

    CAS No.: 18559-94-9 Formula: C13H21NO3 Molecular Weight: 239.31100

    Description

    Salbutamol, also known as albuterol and marketed as Ventolin among other names, is a medication that opens up the medium and large airways in the lungs. It is used to treat asthma, exercise-induced bronchospasm, and chronic obstructive pulmonary disease (COPD). It may also be used to treat high blood potassium levels. It is usually used by inhaler or nebulizer but is also available as a pill and intravenous solution. Onset of action of the inhaled version is typically within 15 minutes and lasts for two to six hours.
    Common side effects include shakiness, headache, fast heart rate, dizziness, and feeling anxious. Serious side effects may include worsening bronchospasm, irregular heartbeat, and low blood potassium levels. It can be used during pregnancy and breastfeeding, but safety is not entirely clear. Salbutamol is a short-acting β2 adrenergic receptor agonist which works by causing airway smooth muscles to relax.
    Salbutamol was first made in 1967 in Britain. It was approved for medical use in the United States in 1982. It is on the World Health Organization's List of Essential Medicines, the most important medication needed in a basic health system. It is available as a generic medication. The wholesale cost in the developing world of an inhaler which contains 200 doses is between $1.12 and $2.64 (USD) as of 2014. In the United States it is between $25 and $50 for a typical month supply.

    Basic Info

    Chemical Name albuterol
    Synonyms

    L-Adrenochrome,free base;
    3,6-dihydroxy-1-methyl-5-oxo-3,5-dihydro-2H-indolium betaine;
    2,3-dihydro-3-hydroxy-1-methyl-1H-indole-5,6-dione;
    3,6-Dihydroxy-1-methyl-5-oxo-3,5-dihydro-2H-indolium-betain;
    3-HYDROXY-1-METHYL-5,6-INDOLINE-DIONE;
    Salbutamol free base;
    3-hydroxy-1-methyl-2,3-dihydro-indole-5,6-dione;
    1-Methyl-3-hydroxyindoline-5,6-dione;
    adrenochrome free base;
    4-(2-(tert-Butylamino)-1-hydroxyethyl)-2-(hydroxymethyl)phenol;
    adraxone;
    3-hydroxy-1-methylindoline-5,6-dione;
    D,L-ADRENOCHROME;
    3-hydroxy-1-methyl-6-indolinedione;

    CAS No. 18559-94-9
    Molecular Formula C13H21NO3
    Molecular Weight 239.31100
    PSA 72.72000
    LogP 1.69690

    Properties

    Appearance & Physical State White to off-white crystalline solid:
    Density 1.152 g/cm3
    Boiling Point 433.5ºC at 760 mmHg
    Melting Point 157-158ºC
    Flash Point 159.5ºC
    Refractive Index 1.566
    Stability Stable, but light sensitive. Incompatible with strong oxidizing agents.
    Vapor Pressure 2.78E-08mmHg at 25°C

    Safety Info

    Hazard Class 6.1(b)
    Safety Statements S36
    HS Code 2922509090
    Packing Group III
    RIDADR UN 3249
    Risk Statements R22
    Hazard Codes Xn

    Synthesis Route

    4-[2-[benzyl(tert-butyl)amino]-1-hydroxyethyl]-2-(hydroxymethyl)phenolalbuterol
    5-(2-tert-Butylamino-acetyl)-2-hydroxy-benzaldehydealbuterol
    salicylaldehydealbuterol

    Precursor

    tert-butylamine
    4-[2-[benzyl(tert-butyl)amino]-1-hydroxyethyl]-2-(hydroxymethyl)phenol
    2-hydroxy-2-(4-hydroxy-3-(hydroxymethyl)phenyl)acetaldehyde
    5-(2-tert-Butylamino-acetyl)-2-hydroxy-benzaldehyde

    Downstream Product

    4-[2-[benzyl(tert-butyl)amino]-1-hydroxyethyl]-2-(hydroxymethyl)phenol

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