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albendazole

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Origin: China

Cas No: 54965-21-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description
  • Synonyms:
    * Albendazolum [INN-Latin],
    * ((Propylthio)-5 1H-benzimidazolyl-2) carbamate de methyle [French],
    * (5-(Propylthio)-1H-benzimidazol-2-yl)carbamic acid methyl ester,  
    * 1503903,   * 220008,   * 5-(Propylthio)-2-carbomethoxyaminobenzimidazole,  
    * AIDS-007895,   * AIDS007895,   * Albendazol [INN-Spanish],  
    * Albendazole (JAN/USP),   * Albendazole [USAN:BAN:INN:JAN],  
    * Albenza,   * Albenza (TN),   * Bilutac,   * C01779, 
    * Carbamic acid, [5- (propylthio)-1H-benzimidazol-2-yl]-, methyl ester,  
    * Carbamic acid, [5-(propylthio)-1H-benzimidazol-2-yl]-, methyl ester,  
    * CHEMBANK1308,   * DRG-0277,   * EINECS 259-414-7,   * Eskazole,  
    * Methyl 5-(propylsulfanyl)-1H-benzimidazol-2-ylcarbamate,  
    * Methyl 5-(propylthio)-2-benzimidazolecarbamate,   * MLS000069722,
    * NSC 220008,   * NSC220008,
    * O-Methyl N-(5-(propylthio)-2-benzimidazolyl)carbamate,  
    * Proftril,   * SK&F 62979,   * SKandF 62979,   * SKF 62979,   * SKF-62979,  
    * SMR000036735,   * Valbazen,  * Zental,   * Zentel,
    * ZINC01821118,   * ZINC01821119,  

    * [5-(Propythio)-1H-benzimidazol-2-yl]carbamic acid methyl ester,

    Chemical Name:
    (5-(Propylthio)-1H-benzimidazol-2-yl)carbamic acid methyl ester
    Molecular Formula:

    C12H15N3O2S

    Molecular Weight :
    265.3294
    CAS No. :
    54965-21-8
    Chemical Structure:
    Specification:
    EP/USP/CP
    Pharmacodynamic
    Properties
    :
    Albendazole is a broad-spectrum anthelmintic for humans and animals. It works by interfering with proteins in either the worm’s intestine or absorptive cells. This leads to the worm not being able to absorb sugar (glucose), which are essential for its survival. Therefore the energy stores of the worm are depleted, and this leads to its eventual death within several days.

    It is used to treat Hydatid disease (echinococcosis) and infection of the nervous system caused by pork tapeworms (neurocysticercosis), also for Hookworm, Ascariasis, Whipworm and Strongyloidiasis.

    Storage:
    Keep container tightly closed in a cool, well-ventilated area.
    MSDS:
    Provide as per request after the order or contract is signed.
  •  

    Property

    CAS No.: 54965-21-8 Formula: C12H15N3O2S Molecular Weight: 265.33100
     

    Description

    Albendazole, marketed as Albenza among others, is medication used for the treatment of a variety of parasitic worm infestations. It is useful for giardiasis, trichuriasis, filariasis, neurocysticercosis, hydatid disease, pinworm disease, and ascariasis, among others. It is taken by mouth.
    Common side effects include nausea, abdominal pains, and headaches. Potentially serious side effects include bone marrow suppression which usually improves on stopping the medication. Liver inflammation has been reported and those with prior liver problems are at greater risk. It is pregnancy category C in the United States and category D in Australia, meaning it may cause harm if taken by a pregnant women. Albendazole is a broad-spectrum antihelminthic agent of the benzimidazole type.
    Albendazole developed in 1975. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. The wholesale cost in the developing world is between 0.01 and 0.06 USD per dose. In the United States, however, it is very expensive as of 2014 at about 50 USD per dose.
     

    Basic Info

    Chemical Name albendazole
    Synonyms

    ALBENZA;
    methyl-5-propylthio-2-benzimidazole carbamate;
    Bruzol;
    methyl N-[5-(propylthio)-1H-benzimidazol-2-yl]carbamate;
    Albendazole;
    ZEBEN;
    methyl 5-(propylthio)benzimidazol-2-ylcarbamate;
    Bilutac;
    ALBEN;
    5-propylthio-2-carbomethoxyaminobenzimidazole;
    Atasol;
    methyl [5-(propylsulfanyl)-1H-1,3-benzimidazol-2-yl]carbamate;
    ZENTEL;
    Monil;

    CAS No. 54965-21-8
    Molecular Formula C12H15N3O2S
    Molecular Weight 265.33100
    PSA 92.31000
    LogP 3.31630
     

    Properties

    Appearance & Physical State Colourless Crystalline Solid
    Melting Point 208-210 °C
    Storage Condition 0-6°C
     

    Safety Info

    RTECS FD1100000
    Safety Statements S53; S45; S37/39; S26
    HS Code 3004909090
    WGK Germany 2
    Risk Statements R61; R36/37/38
    Hazard Codes T
     

    Synthesis Route

    Methylcyanocarbamate+4-propylsulfanylbenzene-1,2-diamine→albendazole
    2-[(methoxycarbonyl)-amino]-1H-benzimidazole-5-sulphonylchloride hydrochloride salt→albendazole
    cyanamide+4-propylsulfanylbenzene-1,2-diamine→albendazole
     

    Precursor

    methyl carbonochloridate
    Methylcyanocarbamate
    2-[(methoxycarbonyl)-amino]-1H-benzimidazole-5-sulphonylchloride hydrochloride salt
    4-propylsulfanylbenzene-1,2-diamine
     

    Downstream Product

    albendazole S-oxide
    6-propylsulfanyl-1H-benzimidazol-2-amine

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