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ajmaline

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Origin: China

Cas No: 4360-12-7

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

Quick Details
CAS No.:
4360-12-7
Other Names:
Ajmaline
MF:
C20H26N2O2
EINECS No.:
224-439-4
Place of Origin:
Shaanxi, China
Type:
Blood System Agents, Cardiovascular Agents
Grade Standard:
Medicine Grade
Brand Name:
XSZO
Model Number:
XSZO-API-105
Purity:
99%
Assay Result:
99.0%~101.0%
Test Method:
HPLC/UV
Test standard:
EP/USP/BP
Certification:
GMP/DMF/COS/ISO
Packaging:
25kgs/Drum
Stock:
In stock
Shelf Life:
2 years
Packaging&Delivery
Packaging Details
5Kgs/Tin; 10Kgs/Carton; 25Kgs/Drum
Port
Any main port of China(Mainland)
Lead Time:
Quantity(Grams) 1 - 1000 >1000
Est. Time(days) 3 To be negotiated

Property

CAS No.: 4360-12-7 Formula: C20H26N2O2 Molecular Weight: 326.43300

Description

Ajmaline (also known by trade names Gilurytmal, Ritmos, and Aritmina) is an alkaloid that is class Ia antiarrhythmic agent. It is often used to bring out typical findings of ST elevations in patients suspected of having Brugada syndrome.
The compound was first isolated by Salimuzzaman Siddiqui in 1931 from the roots of Rauwolfia serpentina. He named it ajmaline, after Hakim Ajmal Khan, one of the most illustrious practitioners of Unani medicine in South Asia. Ajmaline can be found in most species of the Rauwolfia genus as well as Catharanthus roseus. In addition to Southeast Asia, Rauwolfia species have also been found in tropical regions of India, Africa, South America, and some oceanic islands. Other indole alkaloids found in Rauwolfia include reserpine, ajmalicine, serpentine, corynanthine, and yohimbine. While 86 alkaloids have been discovered throughout Rauvolfia vomitoria, ajmaline is mainly isolated from the stem bark and roots of the plant.
Due to the low bioavailability of ajmaline, a semisynthetic propyl derivative called prajmaline (trade name Neo-gilurythmal) was developed that induces similar effects to its predecessor but has better bioavailability and absorption.

Basic Info

Chemical Name	ajmaline
Synonyms	Cartagine; Rytmalin; AJMALINE; Ignazin; Siddiqui; Ritmos; Takycor; Aritmina; Ajmalan-17,21-diol, (17R,21α)-; Tajmalin; Ajmalin;
CAS No.	4360-12-7
Molecular Formula	C20H26N2O2
Molecular Weight	326.43300
PSA	46.94000
LogP	1.55740

Properties

Appearance & Physical State	White solid
Density	1.373g/cm3
Boiling Point	519.406ºC at 760 mmHg
Melting Point	189ºC
Flash Point	285.155ºC
Refractive Index	1.701
Storage Condition	2-8ºC

Safety Info

Hazard Class	6.1(b)
Safety Statements	S13; S45; S36
Packing Group	III
RIDADR	UN 1544
Risk Statements	R25; R20/21/22
Hazard Codes	Xn

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - rat	360 mg/kg	1.Behavioral-altered sleep time (including change in righting reflex) 2.Behavioral-convulsions or effect on seizure threshold 3.Behavioral-ataxia
Intraperitoneal	LD50 - Lethal dose, 50 percent kill	Rodent - rat	94 mg/kg	1.Details of toxic effects not reported other than lethal dose value
Subcutaneous	LD50 - Lethal dose, 50 percent kill	Rodent - rat	216 mg/kg	1.Cardiac-change in rate