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AICAR

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Origin: China

Cas No: 2627-69-2

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
2627-69-2
Other Names:
aicar
MF:
C9H14N4O5
EINECS No.:
2627-69-2
Place of Origin:
Hebei,China
Type:
Vitamins, Amino Acids and Coenzymes
Grade Standard:
Medicine Grade
Usage:
Animal Pharmaceuticals
Brand Name:
TH
Model Number:
TH/1002
Purity:
99%min
Product Name:
Acadesine peptides Aicar
Appearance:
White power
CAS:
2627-69-2
Shelf life:
2 Years
Assay:
99% Min
Storage:
Cool Dry Place
Color:
white
Sample:
Availiable
Grade:
Pharmaceutcial Grade
MOQ:
1box(10vials)
Packaging&Delivery
Packaging Details
Can also according to customer requirements
Port
Qingdao port,Tianjin port
Lead Time:
Quantity(Pieces) 1 - 100 101 - 500 501 - 1500 >1500
Est. Time(days) 7 9 15 To be negotiated
Products Description
Product Name
AICAR powder
other name
AICAR
Appearance
White powder
Purity
99%
stock
avalible

Property

CAS No.: 2627-69-2 Formula: C9H14N4O5 Molecular Weight: 258.23100

Description

Acadesine (INN), also known as 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside, AICA-riboside, and AICAR, is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes.
Acadesine is an adenosine regulating agent developed by PeriCor Therapeutics and licensed to Schering-Plough in 2007 for phase III studies. The drug is a potential first-in-class agent for prevention of reperfusion injury in CABG surgery. Schering began patient enrollment in phase III studies in May, 2009. The trial was terminated in late 2010 based on an interim futility analysis.

Basic Info

Chemical Name	AICAR
Synonyms	AIC-Riboside; Acadesine,AICA; 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside; ACADESINE; Z-RIBOSIDE; GP 1-110; Arasine; AMPK; 5-Amino-1-beta-D-ribofuranosyl-1H-imidazole-4-carboxamide; 5-amino-4-imidazole carboxamide ribonucleoside; AICA-RIBOSIDE;
CAS No.	2627-69-2
Molecular Formula	C9H14N4O5
Molecular Weight	258.23100
PSA	156.85000
LogP	-1.54280

Properties

Appearance & Physical State	Solid
Density	2.06 g/cm3
Boiling Point	726.3ºC at 760 mmHg
Melting Point	214-215ºC
Flash Point	393.1ºC
Refractive Index	1.821
Storage Condition	-20ºC
Vapor Pressure	3.83E-22mmHg at 25°C

Safety Info

Safety Statements	26-36
HS Code	2934999090
WGK Germany	3
Risk Statements	R36/37/38
Hazard Codes	Xi
Caution Statement	P261; P305 + P351 + P338
Hazard Declaration	H315; H319; H335
Signal Word	Warning
Symbol	GHS07

Synthesis Route

9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1-((2-methoxyethoxy)methyl)-1H-purin-6(9H)-one→AICAR
5-azido-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide→AICAR
5-amino-1-(5'-O-tert-butyldimethylsilyl-2',3'-O-isopropylidene-β-D-ribofuranosyl)imidazole-4-carboxamide→AICAR

Precursor

5-azido-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide
5-amino-1-(5'-O-tert-butyldimethylsilyl-2',3'-O-isopropylidene-β-D-ribofuranosyl)imidazole-4-carboxamide
5-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]imidazole-4-carbonitrile
9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1-((2-methoxyethoxy)methyl)-1H-purin-6(9H)-one

Downstream Product

N2-Benzoylguanosine
[(2R,3R,4R,5R)-3,4-diacetyloxy-5-(4-cyano-5-iodoimidazol-1-yl)oxolan-2-yl]methyl acetate
5-Amino-4-imidazolecarboxamide
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxyimidazole-4-carboxamide

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