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Agomelatine

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Origem: China

Cas No: 138112-76-2

Especificação: 99%Min

Quantidade de ordem min: 1 /kg

Capacidade de fornecimento: 100 mt/month

Tempo de espera: 7 dias para OEM, 3 dias para produtos prontos

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  • Property

    CAS No.: 138112-76-2 Formula: C15H17NO2 Molecular Weight: 243.30100

    Description

    Agomelatine is a melatoninergic agonist and selective antagonist of 5-HT2C receptors, and has been shown to be active in several animal models of depression. Agomelatine (S20098) displayed pKi values of 6.4 and 6.2 at native (porcine) and cloned, human (h)5-hydroxytryptamine (5-HT)2C receptors, respectively.

    Basic Info

    Chemical Name Agomelatine
    Synonyms

    Unii-137R1N49ad;
    AGOMELATINE;
    N-[2-(7-Methoxy-1-naphthalenyl)ethyl]-acetamide S-20098;
    AGOMELATIN;
    Valdoxan;
    N-(2-(7-Methoxynaphthalen-1-yl)ethyl)acetamide;
    N-[2-(7-Methoxy-1-naphthalenyl)ethyl]acetamide;

    CAS No. 138112-76-2
    Molecular Formula C15H17NO2
    Molecular Weight 243.30100
    PSA 38.33000
    LogP 2.91790

    Properties

    Appearance & Physical State white solid
    Density 1.109g/cm3
    Boiling Point 478.8ºC at 760 mmHg
    Melting Point 107-109ºC
    Flash Point 243.4ºC

    Safety Info

    HS Code 2924199090

    Synthesis Route

    Acetic anhydride+7-Methoxy-1-naphthylacetonitrile→Agomelatine
    N-[2-(1-hydroxyl-7-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)ethyl]-acetamide→Agomelatine
    2-(7-Methoxynaphthalen-1-yl)ethanamine+Acetic anhydride→Agomelatine

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Oral LD50 - Lethal dose, 50 percent kill Rodent - mouse >1 gm/kg 1.Details of toxic effects not reported other than lethal dose value

    Precursor

    2-(7-Methoxynaphthalen-1-yl)ethanamine
    Acetic anhydride
    N-[2-(7-methoxy-3,4-dihydro-naphthalen-1-yl)ethyl]acetamide
    7-Methoxy-1-naphthylacetonitrile

    Downstream Product

    N-[2-(7-hydroxynaphthalen-1-yl)ethyl]acetamide
    N-[2-(3-bromo-7-methoxynaphthalen-1-yl)ethyl]acetamide

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