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Adapalene Methyl Ester

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Origin: China

Cas No: 106685-41-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Quick Details

    CAS No.:
    106685-41-0
    Other Names:
    adapalene intermediate
    MF:
    C29H30O3
    EINECS No.:
    808-698-6
    Place of Origin:
    China
    Type:
    Pharmaceutical Intermediates
    Purity:
    99%
    Brand Name:
    Royal
    Model Number:
    adapalene intermediate
    Application:
    Used
    Appearance:
    white powder
    Molecular Weight:
    426.55

    Packaging&Delivery

    Packaging Details
    Drum&plastic bags or Aluninium foiled bag&zip lock bag
    Port
    Any port in China
    Lead Time:
    Quantity(Kilograms)1 - 1>1
    Est. Time(days)3To be negotiated

    Products Description

    Product name
    Mehtyl 6-[3-(1-adamanty)-4-methoxy phenyl]-2-naphthoate
    CAS
    106685-41-0
    Molecular Formula
    C29H30O3
    Molecular Weight
    426.55
    Melting Point
    223-225°C

  • Property

    CAS No.: 106685-41-0 Formula: C29H30O3 Molecular Weight: 426.54700

    Description

    Adapalene intermediate, an ester of Adapalene.

    Basic Info

    Chemical Name Adapalene Methyl Ester
    Synonyms

    methyl 6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylate;
    Methyl 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoate;
    Adapalene Related Compound B;
    Methyl 6-(3-(adamantan-1-yl)-4-methoxyphenyl)-2-naphthoate;

    CAS No. 106685-41-0
    Molecular Formula C29H30O3
    Molecular Weight 426.54700
    PSA 35.53000
    LogP 6.76980

    Properties

    Appearance & Physical State White to offwhite Crystal
    Density 1.186 g/cm3
    Boiling Point 589.632ºC at 760 mmHg
    Flash Point 258.722ºC
    Refractive Index 1.627
    Vapor Pressure 0mmHg at 25°C

    Safety Info

    HS Code 2918990090

    Synthesis Route

    methyl 6-bromonaphthalene-2-carboxylate+2-(1-Adamantyl)-4-bromoanisole→1-[5-[3-(1-adamantyl)-4-methoxyphenyl]-2-methoxyphenyl]adamantane+Adapalene Methyl Ester
    methyl 6-bromonaphthalene-2-carboxylate+2-(1-Adamantyl)-4-bromoanisole→Adapalene Methyl Ester
    6-(3-adamantan-1-yl-4-hydroxyphenyl)naphthalene-2-carboxylic acid methyl ester+iodomethane→Adapalene Methyl Ester

    Precursor

    iodomethane
    methyl 6-bromonaphthalene-2-carboxylate
    2-(1-Adamantyl)-4-bromoanisole
    3-(1-Adamantyl)-4-methoxyphenylboronic acid

    Downstream Product

    Adapalene

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