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Acivicin

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Origin: China

Cas No: 42228-92-2

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 42228-92-2 Formula: C5H7ClN2O3 Molecular Weight: 178.57400

Description

Acivicin is an inhibitor of gamma-glutamyl transferase. It is fermented product of Streptomyces sviceus and has promise as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors.

Basic Info

Chemical Name	Acivicin
Synonyms	Antibiotic AT 125; Acivicine; ACIA; Acivicino; AT-125; (2S)-2-amino-2-[(5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl]acetic acid; Acivicinum;
CAS No.	42228-92-2
Molecular Formula	C5H7ClN2O3
Molecular Weight	178.57400
PSA	84.91000
LogP	-0.12460

Properties

Density	1.85g/cm3
Boiling Point	341.6ºC at 760 mmHg
Melting Point	>200ºC (dec.)
Flash Point	160.4ºC
Refractive Index	1.663
Storage Condition	2-8ºC

Safety Info

Hazard Class	6.1(b)
Safety Statements	S36
Packing Group	III
RIDADR	UN 3172
Risk Statements	R20/21/22
Hazard Codes	Xn

Synthesis Route

2-(3-chloro-4,5-dihydro-1,2-oxazol-5-yl)-2-(1,3-dioxoisoindol-2-yl)acetic acid+sec-Butanol→Acivicin
(αS,5S)-α-[(methoxycarbonyl)amino]-3-chloro-4,5-dihydro-5-isoxazoleacetic acid methylidene ester→Acivicin
→Acivicin

Precursor

sec-Butanol

(αS,5S)-α-[(methoxycarbonyl)amino]-3-chloro-4,5-dihydro-5-isoxazoleacetic acid methylidene ester
2-(3-chloro-4,5-dihydro-1,2-oxazol-5-yl)-2-(1,3-dioxoisoindol-2-yl)acetic acid

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Acivicin

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