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acebutolol hydrochloride

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Origin: China

Cas No: 34381-68-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description
  • Property

    CAS No.: 34381-68-5 Formula: C18H29ClN2O4 Molecular Weight: 372.88700

    Description

    Cardioselective β-adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).

    Basic Info

    Chemical Name acebutolol hydrochloride
    Synonyms

    N-(3-Acetyl-4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl)butanamide;
    Acebutolol Hydrochloride;
    N-(3-Acetyl-4-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)butyramide hydrochloride;

    CAS No. 34381-68-5
    Molecular Formula C18H29ClN2O4
    Molecular Weight 372.88700
    PSA 87.66000
    LogP 3.63140

    Properties

    Appearance & Physical State solid
    Boiling Point 564.1ºC at 760 mmHg
    Melting Point 141-143ºC
    Storage Condition 2-8ºC

    Safety Info

    RTECS ES5235000
    Safety Statements S36
    WGK Germany 3
    Risk Statements R20/21/22
    Hazard Codes Xn

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Oral LDLo - Lowest published lethal dose Human - woman 360 mg/kg 1.Cardiac-EKG changes not diagnostic of specified effects
    2.Cardiac-other changes
    3.Lungs, Thorax, or Respiration-acute pulmonary edema
    Oral LD50 - Lethal dose, 50 percent kill Rodent - rat 6620 mg/kg 1.Behavioral-changes in motor activity (specific assay)
    2.Behavioral-ataxia
    3.Lungs, Thorax, or Respiration-respiratory depression
    Intraperitoneal LD50 - Lethal dose, 50 percent kill Rodent - rat 222 mg/kg 1.Behavioral-changes in motor activity (specific assay)
    2.Behavioral-ataxia
    3.Lungs, Thorax, or Respiration-respiratory depression

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