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acarbose

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Origin: China

Cas No: 56180-94-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
56180-94-0
Other Names:
Glucobay
MF:
C25H43NO18
EINECS No.:
260-030-7
Place of Origin:
Hebei, China
Type:
Pharmaceutical Intermediates
Grade Standard:
Food Grade
Brand Name:
HBLV
Model Number:
organic chemical industry
Purity:
99.5%min
Brand::
HBLV
Appearance::
White Powder
Storage::
Cool Dry Place
Form::
crystals
Shelf life::
2 Years
Color::
White
Assay::
99
Application::
Pharmaceutical intermediates
Packaging&Delivery
Packaging Details
250kg/drum
Port
China main port like Shanghai,Tianjin,Shenzhen,etc
Lead Time:
Quantity(Kilograms) 1 - 1 >1
Est. Time(days) 1 To be negotiated

Property

CAS No.: 56180-94-0 Formula: C25H43NO18 Molecular Weight: 645.60500

Description

Acarbose is an anti-diabetic drug used to treat type 2 diabetes mellitus and, in some countries, prediabetes. It is a generic sold in Europe and China as Glucobay (Bayer AG), in North America as Precose (Bayer Pharmaceuticals), and in Canada as Prandase (Bayer AG). It is cheap and popular in China, but not in the U.S. One physician explains the use in the U.S. is limited because it is not potent enough to justify the side effects of diarrhea and flatulence. However, a recent large study concludes "acarbose is effective, safe and well tolerated in a large cohort of Asian patients with type 2 diabetes." A possible explanation for the differing opinions is an observation that acarbose is significantly more effective in patients eating a relatively high carbohydrate Eastern diet ; It is a starch blocker, and inhibits alpha glucosidase, an intestinal enzyme that releases glucose from larger carbohydrates. It is composed of an acarviosin moiety with a maltose at the reducing terminus.

Basic Info

Chemical Name	acarbose
Synonyms	Glucobay; Precos; Acarbose; bay-g5421; Prandase; Precose; Ascarbose; acarviostatin I01;
CAS No.	56180-94-0
Molecular Formula	C25H43NO18
Molecular Weight	645.60500
PSA	321.17000
LogP	-8.17360

Properties

Appearance & Physical State	Off-White Solid
Density	1.74 g/cm3
Boiling Point	971.6ºC at 760 mmHg
Melting Point	165-170ºC
Flash Point	541.4ºC
Refractive Index	1.689
Storage Condition	Store at RT

Synthesis Route

1,2,3,6,2',3',6',2'',3''-nona-O-acetyl-4'',6''-dideoxy-4''-[(1S)-(1,4,6/5)-4,5,6-triacetoxy-3-acetoxymethyl-2-cyclohexenylamino]-α-maltotriose→acarbose
2,3,2',3',6',2'',3''-hepta-O-acetyl-1,6-anhydro-4'',6''-dideoxy-4''-<(1S)-(1,4,6/5)-4,5,6-triacetoxy-3-acetoxymethyl-2-cyclohexenylamino>-β-maltotriose→acarbose

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	TDLo - Lowest published toxic dose	Human - woman	360 mg/kg/60D-I	1.Lungs, Thorax, or Respiration-other changes 2.Liver-liver function tests impaired
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - rat	24 gm/kg	1.Details of toxic effects not reported other than lethal dose value
Subcutaneous	LD50 - Lethal dose, 50 percent kill	Rodent - rat	12 gm/kg	1.Details of toxic effects not reported other than lethal dose value

Precursor

2,3,2',3',6',2'',3''-hepta-O-acetyl-1,6-anhydro-4'',6''-dideoxy-4''-<(1S)-(1,4,6/5)-4,5,6-triacetoxy-3-acetoxymethyl-2-cyclohexenylamino>-β-maltotriose
1,2,3,6,2',3',6',2'',3''-nona-O-acetyl-4'',6''-dideoxy-4''-[(1S)-(1,4,6/5)-4,5,6-triacetoxy-3-acetoxymethyl-2-cyclohexenylamino]-α-maltotriose

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